CD40激动剂改善了放疗联合CTLA4抑制剂诱导的抗肿瘤T细胞初级反应，并增强肿瘤的反应能力。
CD40 agonism improves anti-tumor T cell priming induced by the combination of radiation therapy plus CTLA4 inhibition and enhances tumor response.
发表日期：2023
作者：
Maud Charpentier, Silvia Formenti, Sandra Demaria
来源：
OncoImmunology
摘要：
放射治疗（RT）结合CTLA4阻断剂可以将免疫抑制型（冷瘤）小鼠三阴性乳腺癌（TNBCs）转变为免疫浸润型（热瘤）病变。我们最近的研究表明，针对髓系组织以提高树突状细胞活化是大多数TNBC-bearing小鼠实现RT加CTLA4抑制剂治疗反应显著改善的必要条件。© 2023 The Author(s). 天猫出版集团有限责任公司许可发表。
Radiation therapy (RT) combined with CTLA4 blockers converts immunosuppressed (cold) mouse triple negative breast cancers (TNBCs) into immune infiltrated (hot) lesions. We have recently shown that targeting the myeloid compartment to improve dendritic cell activation is required for most TNBC-bearing mice to achieve superior therapeutic responses to RT plus CTLA4 inhibitors.© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.