IL-32作为皮肤炎症的潜在生物标志物及治疗靶点。
IL-32 as a potential biomarker and therapeutic target in skin inflammation.
发表日期：2023
作者：
Alexandra Wallimann, Mirjam Schenk
来源：
CYTOKINE & GROWTH FACTOR REVIEWS
摘要：
IL-32是一种新近描述的细胞因子，在炎症条件下具有多种功能。已有研究表明血清IL-32在多种疾病包括2型糖尿病、癌症、系统性红斑狼疮、HIV感染以及特应性疾病如特应性皮炎中升高。IL-32有9个不同的亚型，其中IL-32γ是生物活性最高的一个。本综述总结了在皮肤炎症环境中，不同IL-32亚型的各种作用，重点关注特应性皮炎。Copyright © 2023 Wallimann and Schenk.
IL-32 is a recently described cytokine that performs a variety of functions under inflammatory conditions. Serum IL-32 has been shown to be elevated in several diseases, including type 2 diabetes, cancer, systemic lupus erythematosus, HIV infection, and atopic diseases including atopic dermatitis. There are nine different isoforms of IL-32, with IL-32γ being the most biologically active one. The following review summarizes the different roles of the various IL-32 isoforms in the context of skin inflammation, with a focus on atopic dermatitis.Copyright © 2023 Wallimann and Schenk.