研究动态
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对于生物活性陶瓷骨支架的增值光聚合添加制造的综述。

Review on vat photopolymerization additive manufacturing of bioactive ceramic bone scaffolds.

发表日期:2023 Sep 20
作者: Wang Guo, Bowen Li, Ping Li, Lei Zhao, Hui You, Yu Long
来源: Bone & Joint Journal

摘要:

骨缺损在临床中常见,其中包括创伤、疾病、肿瘤和其他原因。然而,自体骨和异体骨的临床应用存在若干限制,如来源有限、供体部位的发病率和免疫排斥等。但是,通过骨组织工程支架和增材制造(AM)技术,即3D打印技术的发展和整合,为再生和修复骨缺损提供了新的希望。尤其是生物活性陶瓷骨支架的VPP-AM近年来引起了跨学科研究者的极大兴趣。一方面,相比其他AM和非AM技术,VPP-AM在打印精度和速度方面具有明显优势。另一方面,生物活性陶瓷材料在生物活性、生物可降解性和机械性能方面优于金属、聚合物和生物惰性陶瓷,使其成为开发骨支架的最有前景的生物材料之一。本文综述了VPP-AM生物活性陶瓷骨支架的研究进展,包括各种VPP-AM技术的过程原理、VPP陶瓷浆料的性能要求和制备过程、生物活性陶瓷骨支架的VPP工艺,以及VPP生物活性陶瓷支架的不同材料类型的研究进展。首先,我们对各种VPP技术的过程原理和医学应用进行简要介绍。其次,我们探讨了VPP陶瓷浆料系统的组成,讨论了各种组分的功能及其对打印质量的影响。第三,我们深入探讨了骨支架的性能要求,并总结了不同材料类型(包括羟基磷灰石(HA)、三磷酸钙(TCP)、生物玻璃(BG)等)的VPP生物活性陶瓷骨支架的研究进展。最后,我们讨论了目前VPP-AM生物活性陶瓷骨支架面临的挑战,并提出了未来可能的发展方向。
Bone defects frequently occur in clinical settings due to trauma, disease, tumors, and other causes. The clinical use of autologous bones and allograft bone, however, has several limitations, such as limited sources, donor site morbidity, and immunological rejection. Nevertheless, there is newfound hope for regenerating and repairing bone defects through the development and integration of bone tissue engineering scaffold and additive manufacturing (AM) technology, also known as 3D printing. In particular, vat photopolymerization (VPP)-AM of bioactive ceramic bone scaffolds has garnered significant interest from interdisciplinary researchers in recent years. On the one hand, VPP-AM demonstrates clear advantages in printing accuracy and speed compared to other AM and non-AM technologies. On the other hand, bioactive ceramic materials exhibit superior bioactivity, biodegradability, and mechanical properties compared to metals, polymers, and bioinert ceramics, making them one of the most promising biomaterials for developing bone scaffolds. This paper reviews the research progress of VPP-AM of bioactive ceramic bone scaffolds, covering the process principles of various VPP-AM technologies, the performance requirements and preparation process of VPP ceramic slurry, the VPP process of bioactive ceramic bone scaffolds, and the research progress on different material types of VPP bioactive ceramic scaffolds. Firstly, we provide a brief introduction to the process principles and medical applications of various VPP technologies. Secondly, we explore the composition of the VPP ceramic slurry system, discussing the function of various components and their effects on printing quality. Thirdly, we delve into the performance requirements of bone scaffolds and summarize the research progress of VPP bioactive ceramic bone scaffolds of various material types including hydroxyapatite (HA), tricalcium phosphate (TCP), bioglass (BG), etc.; Finally, we discuss the challenges currently faced by VPP-AM bioactive ceramic bone scaffolds and propose possible development directions for the future.