寻找新型生理活性咪唑类化合物是医药化学家研究的一个令人兴奋的课题。咪唑环是一种五元芳香杂环，存在于自然和合成化合物中。目前市场上有多种抗癌药物，但由于毒性、疗效有限和溶解度等顾虑，使得整体疗效指数降低。因此，寻找新的潜在化疗药物仍然是一个持续进行的工作。咪唑作为可靠且更安全的替代抗癌治疗方法的开发，受到了专家们的广泛关注。据推测，抑制微管聚合或微管蛋白聚合、改变DNA、VEGF、拓扑异构酶、激酶、组蛋白去乙酰化酶和其他影响基因表达的蛋白结构和功能都可能是咪唑类化合物的潜在靶点。

The quest for novel, physiologically active imidazoles remains an exciting topic of research among medicinal chemists. The imidazole ring is a five-membered aromatic heterocycle that is found in both natural and synthesized compounds. Multiple anticancer drug classes are currently available on the market, but concerns including toxicity, limited efficacy and solubility have lowered the overall therapeutic index. Therefore, the hunt for new potential chemotherapeutic agents persists. The development of imidazole as a reliable and safer alternative to anticancer treatment is generating much attention among experts. Tubulin or microtubule polymerization inhibition and changes in the structure and function of DNA, VEGF, topoisomerase, kinases, histone deacetylases and certain other proteins that affect gene expression are among the putative targets.