本研究的目的是回顾性评估一项跨学科咨询和以精准为基础的运动方案（PEP）对患有稳定和不稳定骨损伤的骨髓瘤患者的影响。分析了根据骨科评估接受PEP的100例骨髓瘤患者（n = 100）的数据。使用现有评分系统（脊柱不稳定肿瘤评分[SINS]，米雷尔斯评分）评估了骨稳定性。所有稳定和不稳定性骨溶解患者均接受了PEP，n = 91的患者进行了随访采访。考虑到60％的患者至少有一个椎骨溶解被认为可能是不稳定或不稳定的。在咨询后，进行抗阻力训练的患者数量显著增加（每周≥2次，55％）。肌肉骨骼疼痛经常出现。在随访采访中，75％的PEP患者表示通过运动可以有效缓解疼痛症状。此外，只有定期锻炼的患者才停止了疼痛药物的使用。与PEP相关的伤害没有报告。我们能够证明个体化的抗阻力训练对骨髓瘤患者是可行和安全的。通过PEP，患者在处理肌肉骨骼疼痛方面的自我效能得到了提高，并且疼痛药物的使用可以减少。© 2023 作者。由John Wiley & Sons Ltd出版的《欧洲血液学杂志》发布。

Aim of this study was to retrospectively evaluate an interdisciplinary consultation followed by a precision-based exercise program (PEP) for myeloma patients with stable and unstable bone lesions.Data of myeloma patients (n = 100) who received a PEP according to an orthopedic evaluation were analyzed. Bone stability was assessed by established scoring systems (Spinal Instability Neoplastic Score [SINS], Mirels' score). All patients with stable and unstable osteolyses received a PEP and n = 91 were contacted for a follow-up interview.In 60% of patients at least one osteolysis of the spine was considered potentially unstable or unstable. Following consultation, the number of patients performing resistance training could be significantly increased (≥2 sessions/week, 55%). Musculoskeletal pain was reported frequently. At the follow-up interview, 75% of patients who performed PEP stated that painful symptoms could be effectively alleviated by exercise. Moreover, only patients who exercised regularly discontinued pain medication. No injuries were reported in association with PEP.We were able to demonstrate that individualized resistance training is implementable and safe for myeloma patients. By means of a PEP, patients' self-efficacy in managing musculoskeletal pain was enhanced and pain medication could be reduced.© 2023 The Authors. European Journal of Haematology published by John Wiley & Sons Ltd.