背景：氨基喹啉核具有多样的药理学特性，特别是在抗癌活性方面。本研究旨在通过靶向HIF-1α信号通路，探讨4-氨基喹啉基框架在抗癌药物开发中的潜力。方法：作者通过微波反应器合成了多个含有杂环环的4-氨基喹啉衍生物，并评估了这些衍生物对HIF-1α信号通路的细胞毒性和抑制效应。结论：化合物3s由于其杰出的抗增殖效果，被鉴定为最有前途的HIF-1α抑制剂，在MiaPaCa-2和MDA-MB-231细胞中观察到的IC50值分别为0.6和53.3 nM。此外，化合物3s通过降低HIF-1α mRNA水平抑制HIF-1α的表达。

Background: The aminoquinoline core exhibits versatile pharmacological properties, particularly in the area of anticancer activity. This study was designed to investigate the potential of the 4-aminoquinoline scaffold in the development of anticancer agents by targeting the HIF-1α signaling pathway. Methodology: The authors synthesized multiple derivatives of 4-aminoquinoline containing heterocyclic rings by a microwave reactor and assessed the cytotoxicity and inhibitory effects of these derivatives on the HIF-1α signaling pathway. Conclusion: Compound 3s was identified as the most promising HIF-1α inhibitor due to its exceptional antiproliferative effects, with IC50 values of 0.6 and 53.3 nM observed in MiaPaCa-2 and MDA-MB-231 cells, respectively. Furthermore, compound 3s was found to inhibit HIF-1α expression by decreasing the level of HIF-1α mRNA.