具有高渗漏的异常肿瘤血管可以促进肿瘤细胞浸润入全身循环，增加肿瘤转移的风险。此外，化疗可能破坏肿瘤血管并进一步加重转移。规范肿瘤血管可以减少血管渗漏并增加血管完整性。同时给予血管规范化药物和化疗药物可以抵抗化疗对血管的破坏。本文制备了结合化疗和肿瘤血管规范化的多功能纳米颗粒（CCM@LMSN/DOX&St），用于乳腺癌的治疗。结果显示，装载St的CCM@LMSN/DOX&St促进了内皮细胞紧密连接蛋白Claudin-4和VE-cadherin的表达，逆转了DOX对内皮细胞层的破坏，保护了内皮细胞层的完整性，并抑制了4T1肿瘤细胞通过内皮细胞层的迁移。体内实验显示，CCM@LMSN/DOX&St有效抑制了原位肿瘤生长，令人激动的是它还抑制了乳腺癌的远端转移。包裹St的CCM@LMSN/DOX&St可以规范肿瘤血管，逆转DOX对肿瘤血管的损伤，增加血管完整性，阻止肿瘤细胞侵入血管，可抑制乳腺癌的自发转移并减少化疗引起的转移。这种药物输送平台有效抑制了肿瘤的进展，并为有效的肿瘤治疗提供了有希望的解决方案。

The abnormal tumor blood vessels with high leakage can promote tumor cells to infiltrate into the systemic circulation and increase the risk of tumor metastasis. In addition, chemotherapy may destroy tumor blood vessels and further aggravate metastasis. Normalizing tumor blood vessels can reduce vascular leakage and increase vascular integrity. The simultaneous administration of vascular normalization drugs and chemotherapy drugs may resist the blood vessels' destruction of chemotherapy. Here, multifunctional nanoparticles (CCM@LMSN/DOX&St), which combined chemotherapy with tumor blood vessel normalization, were prepared for the treatment of breast cancer. The results showed that CCM@LMSN/DOX&St-loaded sunitinib (St) promoted the expression of junction proteins Claudin-4 and VE-cadherin of endothelial cells, reversed the destruction of DOX to the endothelial cell layer, protected the integrity of the endothelial cell layer, and inhibited the migration of 4T1 tumor cells across the endothelial cell layer. In vivo experiments showed that CCM@LMSN/DOX&St effectively inhibited tumor growth in situ; what is exciting was that it also inhibited distal metastasis of breast cancer. CCM@LMSN/DOX&St encapsulated with St can normalize tumor blood vessels, reverse the damage of DOX to tumor blood vessels, increase the integrity of blood vessels, and prevent tumor cell invasion into blood vessels, which can inhibit breast cancer spontaneous metastasis and reduce chemotherapy-induced metastasis. This drug delivery platform effectively inhibited the progression of tumors and provided a promising solution for effective tumor treatment.