本研究的目的是评估BPS/IC（膀胱疼痛综合征/间质性膀胱炎）患女性中焦虑-抑郁障碍的患病率是否高于患有纤维肌痛或其他类型慢性非肿瘤性疼痛的女性，以探究尿路和心理症状之间的可能相关性。参与研究的患者分为两组：1）0组：已确诊为BPS/IC的患者，确认诊断通过查阅医疗记录；1+2组：慢性非肿瘤性疼痛的患者，患有纤维肌痛或其他类型慢性疼痛（慢性关节痛或腰背痛）。使用三个问卷进行调查：PHQ-9问卷评估心理症状，O'Leary Saint问卷（ICSI-ICPI）评估BPS/IC患女性的尿路症状，BPI问卷特别评估疼痛情况。调查共有69名患者，其中42名患者被确诊为BPS/IC，而27名患者患有慢性非肿瘤性疼痛。BPS/IC组的平均PHQ-9分数为10.3，被视为重度抑郁（分数在10到14之间）；1+2组的平均PHQ-9分数为6.9，即亚阈抑郁（分数在5-9之间）。BPS/IC的慢性疼痛可能比其他疼痛情况更影响情绪，因为超过半数的这一人群在PHQ-9问卷中被识别为抑郁，验证了该综合征与焦虑-抑郁病程的患病率较高的假设。

The aim of this study was to evaluate whether there is a higher prevalence of anxiety-depressive disorders in women with BPS/IC (bladder pain syndrome/interstitial cystitis) than in women with chronic non-neoplastic pain with or without fibromyalgia, to examine possible correlations between urological and psychiatric symptoms.The patients included in the study were divided into two groups: 1) group 0: patients with an existing diagnosis of BPS/IC. BPS/IC was confirmed by reviewing medical record; group 1+2: patients with chronic non-neoplastic pain, suffering from fibromyalgia or other types of chronic pain (chronic arthralgia or lower back pain). Three questionnaires were administered: PHQ-9 to investigate psychological symptoms, O'Leary Saint (ICSI-ICPI) to investigate urological symptoms in women with BPS/IC and BPI to investigate specifically pain.The survey included 69 patients, 42 patients had a diagnosis of BPS/IC while 27 of them had chronic non-neoplastic pain. The average PHQ-9 Score was 10.3 in BPS/IC group, considered as major depression (score between 10 and 14); the average score of PHQ-9 was 6.9 in group 1+2, as in sub-threshold depression (between 5-9).The chronic pain of BPS/IC can affect mood more than in other painful conditions, as more than half of this population has a score that identifies depression with the PHQ-9 questionnaire, confirming the hypothesis that the syndrome is associated with a higher prevalence of an anxious-depressive condition.