可操作突变的频率在不同种族之间存在差异，而西班牙语/拉丁裔（H/L）人口是具有不同祖先比例的人群。我们的目的是确定H/L人群中EGFR突变的患病率。我们通过搜索EMBASE，LILACS，MEDLINE和Virtual Health Library截至2023年4月发表的研究来评估H/L患者中ALK，BRAF，EGFR，HER-2，KRAS，MET，NTRK，RET和ROS1的患病率。使用随机效应模型进行荟萃分析，确定患病率。共纳入55篇文章。EGFR和KRAS是最常见的具有高异质性的基因。EGFR的总体突变频率为22%。EGFR基因中最常见的突变为del19（10%）和L858R（7%）。KRAS突变的平均患病率为14%。KRASG12C是最常见的突变，在整个人群中的患病率为7%。ALK重排的总体频率为5%。ROS-1重排的平均频率为2%，HER-2、MET、BRAF、RET和NTRK的分子变异频率分别为4%、3%、2%、2%和1%。近一半的病例为男性，65.8%的病例有吸烟史。最常见的临床分期为IV期。EGFR和KRAS等驱动基因突变在拉美人口中的患病率与亚洲人和欧洲人报道的不同。在本文中，具有高比例美洲印第安祖先的国家相比具有高比例高加索人的国家，EGFR的患病率更高。对某些国家缺乏信息或样本量较小的研究影响了该地区真实的患病率数据。版权所有©2023 Elsevier B.V.。保留所有权利。

The frequency of actionable mutations varies between races, and Hispanic/Latino (H/L) people are a population with different proportions of ancestry. Our purpose was to establish prevalence of actionable mutations in the H/L population with NSCLC.EMBASE, LILACS, MEDLINE, and Virtual Health Library were searched for studies published up to April 2023 that evaluated the prevalence of ALK, BRAF, EGFR, HER-2, KRAS, MET, NTRK, RET, ROS1 in H/L patients. Meta-analyses were done to determine prevalence using a random effects model.Fifty-five articles were included. EGFR and KRAS were the most prevalent genes with high heterogeneity across the countries. The overall mutation frequency for EGFR was 22%. The most frequent mutations in the EGFR gene were del19 (10%) and L858R (7%). The mean of KRAS mutation was a 14% prevalence. KRASG12C was the most frequent mutation with a 7% prevalence in an entire population. The overall frequency of ALK rearrangement was 5%. The mean frequency of ROS-1 rearrangement was 2%, and the frequencies of HER-2, MET, BRAF, RET, NTRK molecular alterations were 4%, 3%, 2%, 2%, and 1% respectively. Almost half of the cases were male, and 65.8% had a history of tobacco exposure. The most common clinical stage was IV.The prevalence of driver mutations such as EGFR and KRAS in LA populations differs from what is reported in Asians and Europeans. In the present article, countries with a high proportion of Amerindian ancestry show a greater prevalence of EGFR in contrast to countries with a high proportion of Caucasians. Lack of information on some countries or studies with a small sample size affects the real prevalence data for the region.Copyright © 2023 Elsevier B.V. All rights reserved.