癌症疼痛是常见的并发症，在癌症患者中常常被低估治疗。本研究的目的是评估通过专科安宁疗护（SPC）实现癌症疼痛管理目标所需的时间。这是一项多中心、前瞻性、纵向研究，针对接受SPC的癌症患者进行了连续随访，直到他们认为癌症疼痛管理达到成功为止，我们使用Kaplan-Meier方法估计了这个时间。我们通过多个患者自报的结果（PROs）和定量测量来调查疼痛管理的有效性，其中包括Brief Pain Inventory中的疼痛强度变化。采用配对样本t检验比较了观察期开始和结束时的疼痛强度。基于PROs的癌症疼痛管理在所有病例中达到了87.9％（385/438）。在这些病例中，94.5％（364/385）在1周内实现了癌症疼痛管理，中位时间为3天（95％置信区间[CI]，2-3）。观察期开始时最近24小时最糟糕的疼痛强度平均为6.9±2.2，结束时为4.0±2.3，差异为-2.9（95％CI，-3.2- -2.6；p<0.01）。总体而言，81.6％的患者对癌症疼痛管理表示满意，共发生了62起不良事件。SPC在短时间内实现了癌症疼痛管理目标，患者满意度高，导致疼痛明显减轻，且记录的不良事件很少。版权所有 © 2023. Elsevier Inc. 发表

Cancer pain is a common complication that is frequently undertreated in patients with cancer.This study is aimed at assessing the time needed to achieve cancer pain management goals through specialized palliative care (SPC).This was a multicenter, prospective, longitudinal study of inpatients with cancer pain who received SPC. Patients were continuously followed up until they considered cancer pain management successful, and we estimated this duration using the Kaplan-Meier method. We investigated the effectiveness of pain management using multiple patient-reported outcomes (PROs) and quantitative measures, including pain intensity change in the Brief Pain Inventory. A paired-sample t-test was used to compare the pain intensity at the beginning and end of the observation period.Cancer pain management based on the PROs was achieved in 87.9% (385/438) of all cases. In 94.5% (364/385) of these cases, cancer pain management was achieved within 1 week, and the median time to pain management was 3 days (95% confidence interval [CI], 2-3). The mean worst pain intensity in the last 24 h at the start and end of observation were 6.9±2.2 and 4.0±2.3, respectively, with a difference of -2.9 (95% CI, -3.2- -2.6; p<0.01). Overall, 81.6% of the patients reported satisfaction with cancer pain management, and 62 adverse events occurred.SPC achieved cancer pain management over a short period with a high level of patient satisfaction resulting in significant pain reduction and few documented adverse events.Copyright © 2023. Published by Elsevier Inc.