美国退伍军人事务局（Veterans Affairs, VHA）正在努力建立一个以邮寄免疫化学粪便检测（FIT）为基础的人群结肠直肠癌筛查计划，用于普通风险患者。然而，对邮寄FIT的低响应率可能会妨碍成功。邮寄FIT计划的关键特点，包括提醒方式，在不同国家的计划中存在差异，而对退伍军人的证据有限。我们旨在测试使用电话呼叫或短信提醒是否能有效提高邮寄FIT的响应率。我们进行了一项前瞻性、随机的质量改进试验（ ClinicalTrials.gov NCT05012007）。那些在收到FIT试剂盒后2周内未退还FIT的退伍军人被随机分为三组：（1）对照组（没有提醒）；（2）自动电话呼叫提醒组；或者（3）自动短信提醒组。共有2658名入读在华盛顿州退伍军人事务局普吉特湾健康保健系统的45-75岁普通风险结肠直肠癌退伍军人。一次自动电话呼叫或短信提醒退伍军人退还FIT试剂盒。我们的主要结果是90天内FIT试剂盒的退还率，次要结果是180天内的FIT试剂盒退还率。参与者的平均年龄为62岁，88%为男性，66%为白人。在90天时，电话和短信提醒干预组的FIT退还率均较对照组更高（意图治疗结果（ITT）：对照组28%，电话提醒组39%，短信提醒组38%；p<0.001）。在180天时，提醒干预组的FIT试剂盒退还率仍较高（ITT：对照组32%，电话提醒组42%，短信提醒组40%；p<0.001）。自动提醒可以提高普通风险退伍军人的结肠直肠癌筛查完成率。自动电话呼叫或短信提醒均有效。打算实施邮寄FIT计划的VHA机构应考虑使用电话或短信提醒，具体取决于可用资源。© 2023。该工作是美国政府工作，在美国没有受版权保护；可能适用外国版权保护。

The Veterans Affairs (VHA) is working to establish a population-based colorectal cancer screening program for average-risk patients using mailed fecal immunochemical testing (FIT). However, low response rates to mailed FIT may hinder success. Key features of mailed FIT programs, including the use of reminders, differ among various national programs, with limited evidence among veterans.We sought to test whether using reminders, either via telephone call or text message, was effective in improving mailed FIT response rates.We conducted a prospective, randomized quality improvement trial ( ClinicalTrials.gov NCT05012007). Veterans who had not returned a FIT within 2 weeks of receiving the kit were randomized to one of three groups: (1) control (no reminder); (2) an automated telephone call reminder; or (3) an automated text message reminder.A total of 2658 veterans enrolled at VA Puget Sound Health Care System who were aged 45-75 and had an average risk of colorectal cancer.A single automated telephone call or text message reminder prompting veterans to return the FIT kit.Our primary outcome was FIT return at 90 days and our secondary outcome was FIT return at 180 days.Participant average age was 62 years, 88% were men, and 66% White. At 90 days, both the phone and text reminder interventions had higher FIT return rates compared to control (intention-to-treat results (ITT): control 28%, phone 39%, text 38%; p<0.001). At 180 days, FIT kit return remained higher in the reminder interventions (ITT: control 32%, phone 42%, text 40%; p<0.001).Automated reminders increased colorectal cancer screening completion among average-risk veterans. An automated phone call or text message was equally effective. VHA facilities seeking to implement a mailed FIT program should consider using phone or text reminders, depending on available resources.© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.