报告19例口腔孤立纤维瘤（SFT）的临床病理特征。临床数据收集自七个病理服务记录。所有病例均经HE染色重新评估并通过免疫组织化学确认。该系列包括11名女性（57.9%）和8名男性（42.1%），平均年龄为47.3±14.7岁（范围：22-71岁），女男比例为1.3:1。大多数肿瘤影响颊粘膜（n=7; 36.8%），在临床上表现为无症状的孤立黏膜下赘块，颜色类似于口腔黏膜。形态学上，大多数SFT（n=10; 52.6%）表现为经典混合样式，其特征为高细胞密度区域与细胞稀少区域在可变的胶原血管结缔组织中交替出现。两例（n=2; 10.5%）观察到副涎腺残余。所有肿瘤对STAT6和CD34阳性（n=19; 100%）。有6名患者（31.6%）提供了随访信息，临床随访时间为6至24个月（平均±标准差为9.5±6.8个月），无一例出现局部复发。口腔SFT罕见且常被临床误诊。病理学家应在口腔纺锤细胞肿瘤的鉴别诊断中考虑SFT。准确的诊断需要仔细的形态学评估，并支持免疫组织化学分析。© 2023 Wiley Periodicals LLC.

To report the clinicopathologic features of 19 oral solitary fibrous tumors (SFTs).Clinical data were collected from the records of seven pathology services. All cases were re-evaluated by HE staining and confirmed by immunohistochemistry.The series comprised 11 females (57.9%) and 8 males (42.1%), with a mean age of 47.3 ± 14.7 years (range: 22-71 years) and a 1.3:1 female-to-male ratio. Most tumors affected the buccal mucosa (n = 7; 36.8%) and presented clinically as an asymptomatic solitary submucosal well-circumscribed nodule with coloration similar to the oral mucosa. Morphologically, most SFTs (n = 10; 52.6%) exhibited a classic hybrid pattern characterized by a well-circumscribed proliferation of densely cellular areas alternating with hypocellular areas in a variably collagenous vascular stroma. Remnants of accessory salivary glands were observed in two cases (n = 2; 10.5%). All tumors were positive for STAT6 and CD34 (n = 19; 100%). Outcome information was available from 6 patients (31.6%), with clinical follow-up ranging from 6 to 24 months (mean ± SD, 9.5 ± 6.8 months), and none developed local recurrence.Oral SFTs are rare and often clinically misdiagnosed. Pathologists should consider SFT in the differential diagnosis of oral spindle cell tumors. Accurate diagnosis requires careful morphological evaluation supported by immunohistochemical analysis.© 2023 Wiley Periodicals LLC.