根据证据，额外骨外Ewing肉瘤（Extraosseous Ewing Sarcoma，EES）在表现模式和预后方面存在年龄差异。因此，我们进行了这项研究，以测试儿童和成人EES病例在临床人口学特征和预后方面的差异。我们探索了4个数据库，共收集到18个相关研究进行数据合成。结果包括比较儿童和成人EES的人口学和临床特征以及预后的差异。对于不同研究间的异质性，我们选择了统计模型/方法。我们的分析包括1261名儿童和1256名成人。当我们比较这两个年龄分类时，我们没有观察到发展EES的风险上的显著差异[对数比（logOR）= -0.13；95%置信区间（CI）：-0.65：0.39；I2 = 88.42%]。关于性别、肿瘤位置和大小（≤5 vs. >5 cm）、EWSR1阳性以及治疗方式等方面也没有显著差异。我们没有观察到临床结果方面（如5年总生存率和无事件生存率、复发、死亡、无疾病证据和继发性转移）的显著差异。我们的研究结果突出了患者年龄类别与EES发病率以及临床预后之间的关联缺失。© 2023 Professor P K Surendran Memorial Education Foundation. Elsevier B.V.保留所有权利。

Evidence suggests different presentation patterns and prognosis of extraosseous Ewing Sarcoma (EES) based on age. Thus, we carried out this study to test the difference between children and adult EES cases regarding clinicodemographic characteristics and prognosis.A total of 4 databases were explored yielding 18 relevant studies for data synthesis. Outcomes included the comparison of demographic and clinical characteristics as well as prognosis between children and adults with EES. Log odds ratio (logOR) and its 95% confidence interval (CI) were pooled across studies. Statistical models/methods were selected based on heterogeneity.Our analysis included a total of 1261 children and 1256 adults. When we compared these two age categories, we did not observe a significant difference in the risk of developing EES [logOR = -0.13; 95% CI: -0.65: 0.39; I2 = 88.42%]. No significant differences regarding gender, tumor location, and size (≤5 vs. >5 cm), EWSR1 positivity, or management modality. We did not observe significant difference regarding clinical outcomes, such as 5-year overall survival and event-free survival, recurrence, mortality, no evidence of disease, and secondary metastasis.Our findings highlight the absence of an association between the age category of patients and the incidence of EES, as well as its clinical outcomes.© 2023 Professor P K Surendran Memorial Education Foundation. Published by Elsevier B.V. All rights reserved.