Jun B原癌基因（JunB）是二聚体活化蛋白-1（AP-1）复合物中至关重要的成员，在多种生理过程中发挥重要作用，如胎盘形成、心血管发育、骨髓造血、血管生成、软骨化骨和表皮组织稳态。此外，已有报道表明JunB通过调节T细胞、树突状细胞和巨噬细胞等免疫细胞的分化和细胞因子分泌，在先天和适应性免疫应答中具有重要的调控功能，同时促进嗜中性粒细胞和自然杀伤细胞的效应。此外，越来越多的研究表明JunB通过调控细胞增殖、分化、衰老和转移等参与肿瘤发生，特别是通过转录促进或抑制肿瘤细胞或免疫细胞的致癌基因来影响肿瘤微环境。本综述总结了JunB的生理功能、免疫调控功能以及其对肿瘤发生的贡献，特别关注其在肿瘤相关免疫过程中的调控机制。版权所有© 2023 Ren, Cai, Yao and Fang.

Jun B proto-oncogene (JunB) is a crucial member of dimeric activator protein-1 (AP-1) complex, which plays a significant role in various physiological processes, such as placental formation, cardiovascular development, myelopoiesis, angiogenesis, endochondral ossification and epidermis tissue homeostasis. Additionally, it has been reported that JunB has great regulatory functions in innate and adaptive immune responses by regulating the differentiation and cytokine secretion of immune cells including T cells, dendritic cells and macrophages, while also facilitating the effector of neutrophils and natural killer cells. Furthermore, a growing body of studies have shown that JunB is involved in tumorigenesis through regulating cell proliferation, differentiation, senescence and metastasis, particularly affecting the tumor microenvironment through transcriptional promotion or suppression of oncogenes in tumor cells or immune cells. This review summarizes the physiological function of JunB, its immune regulatory function, and its contribution to tumorigenesis, especially focusing on its regulatory mechanisms within tumor-associated immune processes.Copyright © 2023 Ren, Cai, Yao and Fang.