CD8阳性T淋巴细胞上的CD39表达可能会影响细胞毒性细胞的功能，导致肿瘤免疫失衡。我们分析了203例肺腺癌患者CD8阳性T淋巴细胞上CD39表达与临床信息的相关性。CD8阳性T淋巴细胞上CD39的表达与T分期、淋巴结转移和远处转移有关。此外，CD39的表达减少了抗肿瘤细胞因子的分泌，促进了PD-1的表达，降低了CD8阳性T淋巴细胞上CD28的表达。本研究证明了CD8阳性T淋巴细胞上CD39作为癌症免疫治疗的负调节因子的潜在价值。版权所有：© 2023 Termedia & Banach。

The function of cytotoxic cells may be impacted by CD39 expression on CD8-positive T lymphocytes, leading to an imbalance in tumor immunity.We analyzed the correlation between the expression of CD39 on CD8-positive T lymphocytes and clinical information in 203 patients with lung adenocarcinoma.The expression of CD39 on CD8-positive T lymphocytes was related to T stage, lymph node metastasis and distant metastasis. Furthermore, the CD39 expression reduced the secretion of antitumor cytokines, promoted PD-1 expression and decreased CD28 expression on CD8-positive T lymphocytes.This research demonstrated the potential value of CD39 on CD8-positive T lymphocytes as a negative regulator in cancer immunotherapy.Copyright: © 2023 Termedia & Banach.