低强度脉冲超声（LIPUS）是一种非常有前景的治疗方法，在康复、骨科、牙科、泌尿学、妇科和其他多学科疾病诊断和治疗中得到了广泛应用, 在全球引起了广泛的关注。然而，目前对LIPUS领域的现状和未来发展方向的综合和系统研究还比较缺乏。因此，本研究采用文献计量学方法全面分析了过去十年来与LIPUS相关的报告，进一步专注于其在内分泌和代谢疾病中的应用进行研究。我们从Web of Science核心合集科学引文索引扩展版和社会科学引文索引中下载了2012年至2022年的LIPUS文献，并使用VOSviewer和CiteSpace等文献计量分析软件执行了分析和可视化结果。我们检索到了655篇英文LIPUS文章，发表于2012年至2022年之间。在这个领域，中国发表的文章数量最多，中国与美国之间的合作最为密切。重庆医科大学是产出最多的机构，而《ULTRASOUND IN MEDICINE AND BIOLOGY》是相关出版物最多的期刊。近年来，对LIPUS的分子机制研究不断深入，其临床应用也不断拓展。LIPUS在氧化应激、再生机制和癌症等重大疾病中的应用被认为是未来的研究方向，尤其是在内分泌和代谢领域，具有广泛的应用价值。全球对LIPUS的研究预计将继续增加，未来的研究将集中在其作用机制和临床应用上。本研究全面总结了LIPUS领域的当前发展状况和全球趋势，以及其在内分泌和代谢疾病领域的研究进展，为该领域未来的研究提供了有价值的参考。版权所有 © 2023 Chu and Niu.

Low-intensity pulsed ultrasound (LIPUS) is a highly promising therapeutic method that has been widely used in rehabilitation, orthopedics, dentistry, urology, gynecology, and other multidisciplinary disease diagnoses and treatments. It has attracted extensive attention worldwide. However, there is currently a lack of comprehensive and systematic research on the current status and future development direction of the LIPUS field. Therefore, this study comprehensively analyzed LIPUS-related reports from the past decade using bibliometrics methods, and further conducted research specifically focusing on its application in endocrine and metabolic diseases.We downloaded LIPUS literature from 2012 to 2022 reported in the Web of Science Core Collection Science Citation Index-Expanded and Social Sciences Citation Index, and used bibliometric analysis software such as VOSviewer and CiteSpace to execute the analysis and visualize the results.We searched for 655 English articles published on LIPUS from 2012 to 2022. China had the highest number of published articles and collaborations between China and the United States were the closest in this field. Chongqing Medical University was the institution with the highest output, and ULTRASOUND IN MEDICINE AND BIOLOGY was the journal with the most related publications. In recent years, research on the molecular mechanisms of LIPUS has continued to deepen, and its clinical applications have also continued to expand. The application of LIPUS in major diseases such as oxidative stress, regeneration mechanism, and cancer is considered to be a future research direction, especially in the field of endocrinology and metabolism, where it has broad application value.Global research on LIPUS is expected to continue to increase, and future research will focus on its mechanisms of action and clinical applications. This study comprehensively summarizes the current development status and global trends in the field of LIPUS, and its research progress in the field of endocrine and metabolic diseases, providing valuable reference for future research in this field.Copyright © 2023 Chu and Niu.