大黄酚是一种天然化合物，存在于多种传统中药中，包括大黄和虎杖。最近的研究表明，大黄酚对多种癌症类型具有强效的抗癌作用，包括肝癌、乳腺癌、肺癌和结肠癌。大黄酚的抗癌作用通过多种机制来介导，包括抑制细胞增殖、诱导细胞凋亡以及抑制肿瘤血管生成和转移。在本综述中，我们对大黄酚的抗癌效应的最新研究进展和新的观点进行了概述。我们总结了目前对大黄酚抗癌活性分子机制的理解，其中包括其对PI3K/Akt、MAPK和NF-[Formula: see text]B通路等信号通路的影响。我们还讨论了大黄酚作为抗癌治疗药物的潜力，包括与常规化疗药物的联合应用以及作为放疗增敏剂的应用。此外，我们还强调了大黄酚衍生物研究的最新进展及其作为新型抗癌剂的潜力。最后，我们讨论了将大黄酚的抗癌特性转化为临床应用的挑战和机会，包括进一步的临床前和临床研究以评估其安全性和有效性。总之，大黄酚是一种具有强效抗癌特性的有希望的天然化合物，其作为抗癌治疗药物的潜力值得进一步研究。本综述提供了当前研究进展和大黄酚抗癌效应的新观点的全面概述，可能为癌症治疗的新型治疗策略的发展提供帮助。

Emodin is a natural compound found in several traditional Chinese medicines, including Rheum palmatum and Polygonum cuspidatum. Recent studies have shown that emodin exhibits potent anticancer effects against a variety of cancer types, including liver, breast, lung, and colon cancer. Emodin's anticancer effects are mediated through several mechanisms, including inhibition of cell proliferation, induction of apoptosis, and suppression of tumor angiogenesis and metastasis. In this review, we provide an overview of recent research progress and new perspectives on emodin's anticancer effect. We summarize the current understanding of the molecular mechanisms underlying emodin's anticancer activity, including its effects on signaling pathways such as the PI3K/Akt, MAPK, and NF-[Formula: see text]B pathways. We also discuss the potential of emodin as a therapeutic agent for cancer treatment, including its use in combination with conventional chemotherapeutic drugs and as a sensitizer for radiotherapy. Furthermore, we highlight recent advances in the development of emodin derivatives and their potential as novel anticancer agents. Finally, we discuss the challenges and opportunities for the translation of emodin's anticancer properties into clinical applications, including the need for further preclinical and clinical studies to evaluate its safety and efficacy. In conclusion, emodin represents a promising natural compound with potent anticancer properties, and its potential as a therapeutic agent for cancer treatment warrants further investigation. This review provides a comprehensive overview of the current research progress and new perspectives on emodin's anticancer effects, which may facilitate the development of novel therapeutic strategies for cancer treatment.