本研究旨在评估和比较辣木叶提取物凝胶（2%）和Retino A乳膏（0.1%）在口腔白斑病变大小减小方面的疗效。本研究旨在评估两种干预措施，辣木叶粘附凝胶和Retino-A乳膏，对口腔白斑病变大小的减小疗效，并具体目标如下：（1）评估辣木叶粘附凝胶在确定病变大小减小方面的疗效，（2）评估Retino-A乳膏在确定病变大小减小方面的疗效，（3）比较辣木叶粘附凝胶（2%）在口腔白斑病变中确定病变大小变化的疗效。本研究纳入临床诊断的口腔白斑病例。样本量为72例，其中36例病变大小在2-4厘米之间，36例病变大小在4.1-6厘米之间，通过卡片系统均匀分配在病例组和对照组中。病例组和对照组各有36例病变大小范围相当的患者。病例组和对照组参与者将被建议每天使用无菌棉签进行干预和Retino-A乳膏的局部应用，每天三次。在治疗口腔白斑病变患者时，发现辣木叶凝胶（2%）与Retino-A相比，在病变大小减小方面更为有效。本研究表明，辣木叶粘附凝胶（2%）是一种对口腔白斑病变患者有效且安全的治疗选择。经过3个月治疗后，与Retino-A乳膏（0.1%）相比，它显著减小了病变大小，没有报告任何不良反应。然而，需要进行长期随访研究以评估其长期效果。辣木叶具有强效的抗氧化性质，使其成为进一步研究中具有浓度变化的其他潜在恶性口腔疾病（如苔藓样锁喉症和OSMF）的有希望的候选药物。还应考虑从辣木叶中开发化疗药物用于癌症治疗。总的来说，辣木叶似乎是口腔白斑的治疗中合成药物的有希望的天然替代品。 白斑病，口腔白斑病，癌前病变，癌前，潜在恶性疾病。

The study aims to evaluate and compare the efficacy of Moringa oleifera leaf extract gel (2%) & Retino A cream (0.1%) in reducing the size of lesions in oral leukoplakia.The present study aimed to evaluate the efficacy of two interventions, Moringa oleifera mucoadhesive gel and Retino-A cream, in reducing the size of lesions in patients with oral leukoplakia. Specifically, the objectives were: (1) to assess the efficacy of Moringa oleifera mucoadhesive gel in determining the reduction in lesion size, (2) to assess the efficacy of Retino-A cream in determining the reduction in lesion size, and (3) to compare the efficacy of Moringa oleifera mucoadhesive gel (2%) in determining the change in lesion size in oral leukoplakia patients.Clinically diagnosed cases of oral Leukoplakia were included in this study. The sample size is 72. Thirty-six patients had lesion sizes ranging from 2- 4 cm, and 36 patients had lesion sizes ranging from 4.1 - 6 cm that were equally distributed in the case and control groups using the chit system. The case and control groups had 36 patients with an equal size range of lesions. The case and control group participants will be advised topical application of the intervention and Retino-A thrice daily using a sterile cotton bud.M. oleifera gel (2%) was found to be more effective in the reduction in the size of the lesion as compared to Retino-A in the treatment of oral leukoplakia patients.This study showed that M. oleifera mucoadhesive gel (2%) is an effective and safe treatment option for oral leukoplakia patients. It demonstrated a significant reduction in lesion size compared to Retino-A cream (0.1%) after 3 months of therapy, without any reported adverse effects. However, long-term follow-up studies are needed to evaluate its long-term effectiveness. The potent antioxidant property of M. oleifera makes it a promising candidate for further studies with concentration variations and in other potentially malignant oral disorders, such as lichen planus and OSMF. The development of chemotherapeutic drugs from M. oleifera for cancer treatment should also be considered. Overall, M. oleifera appears to be a promising natural alternative to synthetic drugs for the treatment of oral leukoplakia.Leukoplakia, Oral leukoplakia, premalignant lesion, precancer, potentially malignant disorders.