胰腺癌是一种致命的、极具侵略性的胃肠道肿瘤，预后不良且治疗选择有限。二硫化物病变是一种新定义的细胞死亡类型，对癌症可能产生影响。有关二硫化物病变与胰腺癌的关联研究非常有限。二硫化物病变相关基因的表达数据从The Cancer Genome Atlas-Pancreatic Adenocarcinoma (TCGA)中下载。通过Cox回归和最小绝对值收缩和选择算子（LASSO）分析，发展出二硫化物病变相关长链非编码RNA签名（DRLS）。评估了高风险组和低风险组之间富集功能、突变谱、免疫微环境和预测治疗效果的差异。应用共识聚类分析来鉴定与DRLS相关的亚型。在98个与二硫化物病变相关的长链非编码RNA中，筛选出了5个长链非编码RNA，构建了一个预后性DRLS。DRLS表现出较高的预测准确性，并且是胰腺癌的独立预后因子。根据从签名计算的风险分数，将样本分为高风险组和低风险组。总体而言，低风险患者预后较好，突变发生率较低，免疫细胞浸润较高，对抗肿瘤药物更敏感。DRLS在预测预后方面表现良好，并揭示了与胰腺癌生物学功能、突变状态和免疫浸润情况的密切相关性，为将来关于二硫化物病变与胰腺癌之间关系的研究提供了一些见解。© 2023年。作者们在Springer Science+Business Media, LLC的独家许可下，属于Springer Nature。

Pancreatic cancer is a lethal, extremely aggressive gastrointestinal tumor with a poor prognosis and limited treatment alternatives. Disulfidptosis is a newly defined type of cell death with potential influence on cancer. Research on the association between disulfidptosis and pancreatic cancer is scarce. The expression data of disulfidptosis-related genes were downloaded from The Cancer Genome Atlas-Pancreatic Adenocarcinoma (TCGA). Disulfidptosis-related lncRNA signature (DRLS) was developed through the Cox and the least absolute shrinkage and selection operator (LASSO) analysis. Differences in enrichment functions, mutational landscape, immune microenvironment, and predicted therapeutic efficacy between high- and low-risk groups were assessed. Consensus clustering analysis was applied to identify the DRLS-related subtypes. Among 98 disulfidptosis-related lncRNAs, 5 lncRNAs were screened thus constructing a prognostic DRLS. DRLS showed high predictive accuracy and was an independent prognostic factor for pancreatic cancer. According to the risk scores calculated from the signature, samples were categorized into high- and low- risk groups. Overall, low-risk patients had a better prognosis, lower mutational occurrences, higher immune cell infiltration and more sensitivity to anti-tumor agents. The DRLS performed well in predicting prognosis and revealed intimate correlation with biological function, mutation status and immune infiltration landscape of pancreatic cancer, providing some insights for future research on the relationship between disulfidptosis and pancreatic cancer.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.