10名患者试验：儿科癌症疗效显著。
10-Patient Trial: Remarkable Responses in Pediatric Cancers.
发表日期：2023 Sep 21
作者：
Elaine R Mardis
来源：
Best Pract Res Cl Ob
摘要：
一项针对10名高肿瘤突变负荷的小儿肿瘤患者的尼伐单抗临床试验显示，50%的患者达到了完全缓解。这一结果重现了多个高突变负荷的成人肿瘤临床试验的结果，并可能在基于胚系DNA错配修复敏感性的背景下重新定义最佳实践。
A clinical trial of Nivolumab in 10 pediatric cancer patients with high tumor mutational burden demonstrated complete responses in 50% of patients. This result recapitulates multiple clinical trial results in high mutation burden adult cancers and may redefine best practice in the setting of germline DNA mismatch repair-based susceptibility.