研究动态
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评估术中乳腺放疗对局部复发的影响:一项巴西队列研究。

Evaluation of intraoperative breast radiotherapy on local recurrence: a Brazilian cohort.

发表日期:2023 Sep 21
作者: Cintia Melo Sousa, Izabella Nobre Queiroz, Ana Paula Drummond-Lage
来源: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

摘要:

评估2007年至2017年期间在巴西贝洛奥里藏特的单一私立医疗机构接受术中全身电子放疗(IOERT)的乳腺癌女性患者的局部复发率和全球生存率。本研究是一项基于病历的回顾性研究,研究对象是接受保乳手术后进行IOERT的患者。收集的变量包括患者的个人资料和肿瘤特征、IOERT剂量分布、以及治疗结果。定量数据以频率表的形式呈现。生存曲线采用Kaplan-Meier方法绘制。在所有的检验中,所采用的显著性水平为5%。统计分析采用SPSS 25.0版本进行。研究样本共有78名患者,其中有14例(17.9%)复发。IOERT执行后的中位复发时间为49个月。在分析的78名患者中,有13例(16.7%)死亡,其中5例(6.4%)是由乳腺癌所致。5年内的全球生存率为94.9%,10年内为90.4%。5年内的局部复发率为89.7%,10年内为86.4%。我们的研究结果显示,本地复发率较文献数据更高。然而,我们的结果也显示,低风险患者的5年和10年总体生存率与文献中的其他研究相似,这证实了低风险女性可以从IOERT中受益。鉴于这一发现,重申IOERT的严格适应症对于减少局部复发至关重要。
Assess the local recurrence rate and global survival rate among women diagnosed with breast cancer who underwent intraoperative electron radiotherapy (IOERT) between 2007 and 2017, in a single private healthcare setting in Belo Horizonte, Brazil.This is a retrospective study based on medical records about the outcomes of patients submitted to breast-conserving surgery followed by IOERT. The collected variables included the patient's profile and tumor features, IOERT isodose, and outcomes. The quantitative data were presented in tables of frequency. The survival curves were created with the Kaplan-Meier method. In all tests, the adopted relevance level was 5%. The analyses were carried out with SPSS version 25.0.The samples consisted of 78 patients, among which a total of 14 (17.9%) recurrences were observed. The median time of recurrence was 49 months after the IOERT was performed. Of the 78 patients analyzed, 13 (16.7%) died, 5 (6.4%) of which were due to breast cancer. The global survival rate in 5 years was 94.9% and 90.4% in 10 years. The local recurrence rate in 5 years was 89.7% and 86.4% in 10 years. Our findings revealed a higher local recurrence rate than the literature data. However, our results also showed that patients classified as low-risk had an overall survival of 5 and 10 years similar to other studies in the literature, reaffirming that low-risk women can benefit from IOERT. Given this finding, it is reaffirmed that rigorous eligibility criteria for IOERT are critical to reducing local recurrence.