我们的目的是描述具有黏液表皮样癌（MEC）特征以及与口腔表面黏膜连续的组织学和临床特征。我们回顾了138例口腔内黏液表皮样癌的病例，以识别展现表面黏膜连续性的病例，并将它们的临床和人口学特征与没有连续性的黏液表皮样癌进行比较。我们使用双样本Z检验比较性别比例，并使用双样本Kolmogorov-Smirnov检验比较年龄分布。 在138例病例中，有14例展现出与表面黏膜连续性。它们的组织学显示表面黏膜向浸润性肿瘤过渡，伴有黏液、中间型和表皮型肿瘤细胞以实性和囊性模式生长。它们的临床表现范围从坚实的黏膜下结节到红斑和溃疡病变。它们显示出明显的女性偏好（6:1）和双峰年龄分布，第四和第七十年龄段呈尖峰。 展现连续性的黏液表皮样癌具有与常规黏液表皮样癌不同的人口学特征，显示出明显的女性偏好和双峰年龄分布，提示可能存在病因差异。病理学家应意识到，口腔中的黏液表皮样癌可能具有表面起源的组织学特征，以便作出正确的诊断。 版权所有 © 2023 Elsevier Inc. 保留所有权利。

We aimed to characterize the histology and the clinicodemographic features of mucoepidermoid carcinoma (MEC), showing continuity with the oral surface mucosa.We reviewed 138 cases of intraoral MEC to identify cases that showed continuity with the surface mucosa and compared their clinicodemographic findings with those of MECs not showing continuity. We compared the sex ratio using the 2-sample Z-test and compared the age distribution using the 2-sample Kolmogorov-Smirnov test.Of the 138 cases examined, 14 showed continuity with the surface mucosa. Their histology showed surface mucosa with an apparent transition to an infiltrating tumor with mucous, intermediate, and epidermoid tumor cells growing in solid and cystic patterns. Their clinical appearance ranged from firm submucosal nodules to erythematous to ulcerated lesions. They showed a strong female predilection (6:1) and sharply bimodal age distribution, with sharp peaks in the fourth and seventh decades.Mucoepidermoid carcinomas that show continuity have a demographic pattern distinct from that of conventional MECs, showing a striking female predilection and bimodal age distribution and suggesting a difference in etiology. Pathologists should remain aware that MEC in the oral cavity can have a histologic appearance of surface origin to reach the correct diagnosis.Copyright © 2023 Elsevier Inc. All rights reserved.