尽管在肿瘤治疗方面取得了一些进展，但胶质瘤仍然是一种严重威胁人类生命和健康的肿瘤之一。由于中枢神经系统免疫微环境的特殊性和肿瘤的强侵袭性，胶质瘤的治疗仍然是一个重大挑战。目前，研究人员已经探索了大量的免疫疗法方案，以改善胶质瘤患者的生存和预后，包括肿瘤疫苗、免疫检查点抑制剂、细胞转移免疫疗法、病毒载体疗法和基因工程疗法。这些方案的目标是通过药物激活或改变免疫抑制环境，并结合手术切除、放疗、化疗和抗血管生成的药物，以达到治疗胶质瘤的目的。本综述简要描述了胶质瘤的免疫抑制微环境，并总结了近期免疫治疗策略及其进展。旨在总结治疗胶质瘤的最新免疫疗法并提供新的研究方向。© 2023 The Author(s). Published by IMR Press.

Although some progress has been made in tumor treatment, gliomas remain one of the tumors that can still seriously threaten human life and health. Due to the particularity of the immune microenvironment of the central nervous system and the strong invasiveness of tumors, the treatment of gliomas remains a major challenge. Currently, researchers have explored a large number of immunotherapy programs to improve the survival and prognosis of glioma patients, including tumor vaccines, immune checkpoint inhibitors, adoptive cell transfer therapy, viral vector therapy, and genetic engineering therapy. The goal of these programs is to activate or change the immunosuppressive environment and target tumor cells through drugs, combined with surgical resection, radiotherapy, chemotherapy, and anti-angiogenesis drugs, to achieve the purpose of treating glioma. This review briefly describes the immunosuppressive microenvironment of gliomas and summarizes recent immunotherapeutic strategies and their progress. The aim is to summarize the latest immunotherapies for the treatment of gliomas and provide new research directions.© 2023 The Author(s). Published by IMR Press.