当前神经退行性疾病治疗中最具挑战性的问题之一与治疗剂对中枢神经系统 (CNS) 的渗透和进入受限于血脑屏障 (BBB) 相关。最近，经由鼻内 (IN) 运输开辟了直接通过嗅觉途径将药物送入脑部治疗神经系统疾病的新前景。近年来，基于PLGA纳米载体的IN输送药物获得了很多关注。本综述收集了有关不同研发的基于PLGA纳米载体的IN输送药物在阿尔茨海默病、帕金森病、脑肿瘤、缺血、癫痫、抑郁症和精神分裂症等脑疾病治疗中的最新进展的清晰和简洁陈述。随后，对基于PLGA的IN给药的未来展望和挑战进行了简要讨论。

One of the most challenging problems of the current treatments of neurodegenerative diseases is related to the permeation and access of most therapeutic agents to the central nervous system (CNS), prevented by the blood-brain barrier (BBB). Recently, intranasal (IN) delivery has opened new prospects because it directly delivers drugs for neurological diseases into the brain via the olfactory route. Recently, PLGA-based nanocarriers have attracted a lot of interest for IN delivery of drugs. This review gathered clear and concise statements of the recent progress of the various developed PLGA-based nanocarriers for IN drug delivery in brain diseases including Alzheimer's, Parkinson's, brain tumors, ischemia, epilepsy, depression, and schizophrenia. Subsequently, future perspectives and challenges of PLGA-based IN administration are discussed briefly.