癌症干细胞（CSCs）具备自我更新、分化和产生新肿瘤的能力，这是导致药物抵抗、复发和转移的重要原因。因此，针对CSCs进行治疗的目标性尤其重要。最近的研究表明CSCs比非CSCs更容易发生铁过氧化物致死，这表明这可能是治疗肿瘤的有效策略。铁过氧化物致死是一种由细胞内铁介导的过氧化脂质积累导致的程序性细胞死亡。CSCs表现出与铁和脂质代谢相关的不同分子特征。本研究回顾了CSCs中铁代谢、脂质过氧化和脂质过氧化物清除的变化，以及其对铁代谢和铁过氧化物致死的调节机制。还讨论了通过诱导铁过氧化物致死来靶向CSCs的潜在治疗策略和新化合物。版权 © 2023 王、张、阮、严、陈、崔、王、黄和侯。

The ability of cancer stem cells (CSCs) to self-renew, differentiate, and generate new tumors is a significant contributor to drug resistance, relapse, and metastasis. Therefore, the targeting of CSCs for treatment is particularly important. Recent studies have demonstrated that CSCs are more susceptible to ferroptosis than non-CSCs, indicating that this could be an effective strategy for treating tumors. Ferroptosis is a type of programmed cell death that results from the accumulation of lipid peroxides caused by intracellular iron-mediated processes. CSCs exhibit different molecular characteristics related to iron and lipid metabolism. This study reviews the alterations in iron metabolism, lipid peroxidation, and lipid peroxide scavenging in CSCs, their impact on ferroptosis, and the regulatory mechanisms underlying iron metabolism and ferroptosis. Potential treatment strategies and novel compounds targeting CSC by inducing ferroptosis are also discussed.Copyright © 2023 Wang, Zhang, Ruan, Yan, Chen, Cui, Wang, Huang and Hou.