世界范围内结直肠癌（CRC）的发病率和死亡率迅速上升。近年来，对N6-甲基腺苷（m6A）这一最常见的mRNA修饰引起了广泛关注，特别是对其在CRC发展中的影响。值得注意的是，在肿瘤微环境（TME）的作用下，CRC的进展将受到严重阻碍。CRC细胞与其周围环境之间的相互作用可以激活和影响复杂的表观遗传变化信号机制，以影响恶性表型的肿瘤细胞的生存。此外，TME受m6A调控因子的影响，对CRC的进展和预后产生影响。在本综述中，我们描述了m6A修饰与CRC的代谢、缺氧、炎症和免疫微环境之间的相互作用和具体机制。此外，我们总结了m6A修饰在CRC微环境中发挥的治疗作用，并讨论了该领域的目前状况、局限性和潜在未来发展方向。本综述旨在为CRC治疗的分子靶点和理论基础提供新的见解。© 2023. 美国范斯坦医学研究所。

The incidence and mortality of colorectal cancer (CRC) are rapidly increasing worldwide. Recently, there has been significant attention given to N6-methyladenosine (m6A), the most common mRNA modification, especially for its effects on CRC development. It is important to note that the progression of CRC would be greatly hindered without the tumor microenvironment (TME). The interaction between CRC cells and their surroundings can activate and influence complex signaling mechanisms of epigenetic changes to affect the survival of tumor cells with a malignant phenotype. Additionally, the TME is influenced by m6A regulatory factors, impacting the progression and prognosis of CRC. In this review, we describe the interactions and specific mechanisms between m6A modification and the metabolic, hypoxia, inflammatory, and immune microenvironments of CRC. Furthermore, we summarize the therapeutic role that m6A modification can play in the CRC microenvironment, and discuss the current status, limitations, and potential future directions in this field. This review aims to provide new insights into the molecular targets and theoretical foundations for the treatment of CRC.© 2023. The Feinstein Institute for Medical Research.