粒子治疗（PT）具有良好的剂量分布和高治愈率。然而，对于与胃肠道相邻的恶性肿瘤，放射治疗因其低耐受性而被禁忌。为了克服这一问题，已经发展了结合手术切除使肿瘤与邻近胃肠道之间产生空隙后进行PT的综合治疗方法。已经使用了几种材料作为填充剂，我们最近开发的可吸收聚乙二醇酸（PGA）填充剂自2019年以来一直在使用。本研究是连续病例系列使用PGA填充剂进行填充剂植入手术的首次报告。 对接受PGA填充剂植入手术的50例连续患者进行了评估。评估了术后实验室数据，与治疗相关的发病率以及治疗后的填充剂体积。 没有与治疗相关的死亡，除两例患者外，所有患者都完成了综合治疗。术后PGA填充剂体积与治疗前体积的中位比率分别为96.9％，87.7％和74.6％，分别在第2、4和8周。填充剂体积在第7周保持在80％，预计在第15周为50％，在第24周为20％。 使用PGA填充剂进行填充剂植入手术是可行且可耐受的。PGA填充剂在随后的PT期间保持了足够的厚度。使用PGA填充剂的综合治疗是创新的，具有成为新的标准根治性局部治疗的潜力。 版权所有 © 2023 年由美国外科医师学院。由 Wolters Kluwer Health，Inc. 发布。保留所有权利。

Particle therapy (PT) has favorable dose distribution and high curability. However, radiotherapy for malignant tumors adjacent to the gastrointestinal tract is contraindicated owing to its low tolerance. To overcome this, combination treatment with surgery to make a space between the tumor and adjacent gastrointestinal tract followed by PT has been developed. Several materials have been used for the spacer, and we have recently developed the absorbable polyglycolic acid (PGA) spacer, which has been used since 2019. This study is the first report of consecutive case series of spacer placement surgery using the PGA spacer.Fifty consecutive patients undergoing spacer placement surgery with the PGA spacer were evaluated. Postoperative laboratory data, morbidity related to the treatment, and spacer volume after treatment were evaluated.There were no treatment-related deaths, and all but two patients completed combination treatment. The median ratios of post-operative PGA spacer volume to the pre-treatment volume were 96.9%, 87.7%, and 74.6% at weeks 2, 4, and 8, respectively. The spacer volume was maintained at 80% at 7 weeks and was predicted to be 50% at 15 weeks and 20% in 24 weeks.Spacer placement surgery using the PGA spacer was feasible and tolerable. The PGA spacers maintained sufficient thickness during the duration of subsequent PT. Combination treatment using the PGA spacer is innovative and has the potential to become a new standard curative local treatment.Copyright © 2023 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.