异常的短暂和长时间睡眠与早逝有关，并且实现理想的睡眠时长一直是睡眠健康指南的关注重点。新兴研究表明，睡眠规律，即日常的睡眠-清醒时间一致性，可能比睡眠时长对某些健康结果更具有预测力。然而，睡眠规律在死亡率中的作用尚未在大型队列中进行具有客观数据的研究。因此，我们的目标是比较睡眠规律和时长对全因和特定原因死亡风险的预测能力。我们从60,977名英国生物银行参与者的>10百万小时的加速度计数据中计算了睡眠规律指数（SRI）分数（62.8 ± 7.8岁，女性占55.0％，中位数[IQR] SRI：81.0 [73.8-86.3]）。在1,859名参与者（每1000人年报告的死亡率为4.84，平均（±SD）随访时间为6.30 ± 0.83年）的加速度计记录之后的7.8年内报告了死亡情况。较高的睡眠规律与全因死亡风险降低20-48％（p <.001至p = 0.004），癌症死亡风险降低16-39％（p <0.001至p = 0.017），以及心脏代谢性死亡风险降低22-57％（p <0.001至p = 0.048），与最不规律的五分位向量相比。结果经过年龄、性别、种族、社会经济、生活方式和健康因素的调整。通过比较等效死亡模型，以及具有和不具有睡眠时长的嵌套SRI-死亡模型的比较（p = 0.14-0.20），睡眠规律在全因死亡率的预测中比睡眠时长更为重要。这些发现表明，睡眠规律是预测死亡风险的重要因素，且比睡眠时长更具预测力。睡眠规律可能是改善一般健康和生存的简单有效目标。© The Author(s) 2023. 由牛津大学出版社代表睡眠研究学会发表。

Abnormally short and long sleep are associated with premature mortality, and achieving optimal sleep duration has been the focus for sleep health guidelines. Emerging research demonstrates that sleep regularity, the day-to-day consistency of sleep-wake timing, can be a stronger predictor for some health outcomes than sleep duration. The role of sleep regularity in mortality, however, has not been investigated in a large cohort with objective data. We therefore aimed to compare how sleep regularity and duration predicted risk for all-cause and cause-specific mortality. We calculated Sleep Regularity Index (SRI) scores from >10 million hours of accelerometer data in 60,977 UK Biobank participants (62.8±7.8 years, 55.0% female, median[IQR] SRI: 81.0[73.8-86.3]). Mortality was reported up to 7.8 years after accelerometer recording in 1,859 participants (4.84 deaths per 1000 person-years, mean (±SD) follow up of 6.30±0.83 years). Higher sleep regularity was associated with a 20-48% lower risk of all-cause mortality (p<.001 to p=0.004), a 16-39% lower risk of cancer mortality (p<0.001 to p=0.017), and a 22-57% lower risk of cardiometabolic mortality (p<0.001 to p=0.048), across the top four SRI quintiles compared to the least regular quintile. Results were adjusted for age, sex, ethnicity, and sociodemographic, lifestyle, and health factors. Sleep regularity was a stronger predictor of all-cause mortality than sleep duration, by comparing equivalent mortality models, and by comparing nested SRI-mortality models with and without sleep duration (p=0.14-0.20). These findings indicate that sleep regularity is an important predictor for mortality risk and is a stronger predictor than sleep duration. Sleep regularity may be a simple, effective target for improving general health and survival.© The Author(s) 2023. Published by Oxford University Press on behalf of Sleep Research Society.