以木质结构为灵感的可注射性木质素基纳米凝胶作为血管栓塞持续释放药物的支架，用于肝癌介入治疗。
Wood structure-inspired injectable lignin-based nanogels as blood-vessel-embolic sustained drug-releasing stent for interventional therapies on liver cancer.
发表日期：2023 Sep 14
作者：
Ze Zheng, Hongsen Zhang, Kun Qian, Ling Li, Dingwen Shi, Ran Zhang, Ling Li, Hongbo Yu, Chuansheng Zheng, Shangxian Xie, Yanbing Zhao, Xiangliang Yang
来源：
BIOMASS & BIOENERGY
摘要：
迫切需要一种易注入、目标栓塞控制良好、化疗药物持续释放的栓塞试剂，以成功进行经动脉化疗栓塞治疗(TACE)。然而，开发具有高度有效性的栓塞试剂仍面临挑战。 在这里，受到木质细胞壁的结构支撑性和防御机制的启发和指导，探索了一种理想的以木质素为基础的栓塞纳米凝胶(DOX-pN-KL)。基于分枝木质素的机械支撑和木质素芳香环与抗肿瘤药物阿霉素(DOX)之间的π-π堆积力的作用，DOX-pN-KL在已报告的热敏栓塞纳米凝胶中表现出最高的机械强度，并具有高载药量和有利的持续释放性能。此外，对VX2肿瘤兔的TACE治疗和肿瘤微环境评估进一步表明，该纳米凝胶能够长期完全阻断所有层次的血管，持续释放DOX，从而对肿瘤生长和转移具有有效抑制作用。预计DOX-pN-KL将成为介入治疗的有希望的替代试剂。版权所有 © 2023 Elsevier Ltd. All rights reserved.
An embolic reagent with easy injection, well-controlled target embolization, and sustained release of chemotherapy drugs is urgently needed for successful trans-arterial chemo-embolization (TACE) treatment. However, the development of a highly effective embolic reagent is still challenged. Here, inspired and guided by the structural supporting properties and defense mechanisms of wood cell walls, an ideal lignin-based embolic nanogel (DOX-pN-KL) was explored. Based on the mechanical support of branched lignin and the π-π stacking force between the lignin aromatic ring with anti-tumor drug doxorubicin (DOX), DOX-pN-KL showed the highest mechanical strength among the reported thermosensitive embolization nanogel and performed high drug-loading and favorable sustained-release. Moreover, further TACE treatment and tumor microenvironment evaluation of VX2 tumor-bearing rabbits showed that this nanogel can completely block all levels of vessels in long term and continuously release DOX, thus having effective inhibition on tumor growth and metastasis. DOX-pN-KL is expected to be a promising alternative reagent for interventional therapy.Copyright © 2023 Elsevier Ltd. All rights reserved.