破译癌症的“安全带”：连接脂质代谢和抗原呈递
Un-FASN-ing cancer's seat belt: Linking lipid metabolism and antigen presentation.
发表日期：2023 Sep 21
作者：
Zachary Corey, Elyse Schechter, Raphael A Nemenoff
来源：
Cell Chemical Biology
摘要：
癌细胞上的MHC-II表达与治疗结果的改善相关。在本期中，黄等人报告了一系列小分子，通过抑制脂肪酸合酶（FASN）选择性上调癌细胞上的MHC-II，从而抑制肿瘤生长。针对脂代谢与抗原呈递之间的这一联系可能改善对免疫疗法的响应。版权所有 © 2023 Elsevier Ltd. 保留所有权利。
MHC-II expression on cancer cells is associated with improved treatment outcome. In this issue, Huang et al.1 report a panel of small molecules that selectively upregulate MHC-II on cancer cells through suppression of fatty acid synthase (FASN), resulting in inhibition of tumor growth. Targeting this link between lipid metabolism and antigen presentation may improve response to immunotherapy.Copyright © 2023 Elsevier Ltd. All rights reserved.