脂质过氧化的增加报告突出了在具有挑战性的癌症中的脆弱性。在这种情况下，FSP1作为一个关键的调节因子出现，积极对抗脂质过氧化的破坏效应。在最新一期的《细胞化学生物学》杂志中，Hendricks等人详细介绍了FSEN1，一个有效的FSP1抑制剂的突破性发现。FSEN1的发现具有巨大的潜力，因为它能与GPX4抑制剂以及其他几种FDA批准的药物协同作用，增强它们诱导耐药癌细胞铁死亡的能力。这对于在临床前阶段的铁死亡为基础的策略来说是一个重大的进展。版权所有 © 2023 Elsevier Ltd. 保留所有权利。

The report of heightened lipid peroxidation has shone a spotlight on vulnerabilities within challenging cancers. In this context, FSP1 emerges as a pivotal regulator, actively countering the destructive effects of lipid peroxidation. In a groundbreaking development detailed in the latest issue of Cell Chemical Biology, Hendricks et al. unveil FSEN1, a potent inhibitor of FSP1. The discovery of FSEN1 holds tremendous promise as it synergizes with GPX4 inhibitors, in addition to several FDA-approved drugs, amplifying their capacity to induce ferroptosis in resistant cancer cells. This represents a significant stride towards ferroptosis-based strategies in preclinical settings.Copyright © 2023 Elsevier Ltd. All rights reserved.