谷氨酰胺的供应释放树突状细胞的抗肿瘤能力。
Glutamine availability unleashes dendritic cells' anti-tumor power.
发表日期：2023 Sep 21
作者：
Mauro Corrado, Christian Frezza
来源：
Cell Chemical Biology
摘要：
肿瘤微环境（TME）中的代谢竞争塑造了抗癌免疫的疗效。在《自然》杂志8月3日的报道中，郭等人（1）表明谷氨酰胺是癌细胞和免疫细胞之间的细胞间代谢检查站。针对肿瘤微环境中的谷氨酰胺代谢是改善抗癌治疗的有希望的策略。版权所有 © 2023 Elsevier Ltd. 保留所有权利。
Metabolic competition within the tumor microenvironment (TME) shapes the efficacy of anticancer immunity. In the August 3rd issue of Nature, Guo et al.1 show that glutamine is an intercellular metabolic checkpoint between cancer and immune cells. Targeting glutamine metabolism in the TME is a promising strategy to improve anti-cancer therapy.Copyright © 2023 Elsevier Ltd. All rights reserved.