丁香科物种和梧桐属（樟科）是广泛发现具有环戊烷和非常规的反式-5/6环连接的丁香烷倍半萜单体和寡聚物的主要来源。大量研究表明，丁香烷倍半萜单体和寡聚物具有广泛的生物活性，如细胞毒性、抗炎、神经保护、抗真菌和抗疟活性。本综述从1925-2023年对丁香醇进行首次鉴定的出版物进行总结，并将丁香烷倍半萜衍生物分类为丁香烷单体、丁香烷-单萜偶联物、丁香烷同源二聚体、丁香烷异源二聚体和三聚体丁香烷倍半萜。此外，总结了它们的生物活性。本综述将为利用这一独特类别的天然产物作为潜在的首选化合物，并发展其在治疗炎症、癌症和疟原虫相关疾病中的应用提供科学依据和指导。版权所有 © 2023。由Elsevier Ltd.出版。

Lindenane sesquiterpenoid monomers and oligomers, characterized by a sterically congested cyclopentane and an unusual trans-5/6 ring junction, are mainly found in Chloranthaceae species and the genus Lindera Thunb (Lauraceae). Numerous studies have shown that lindenane sesquiterpenoid monomers and oligomers exhibit a broad range of biological activities, such as cytotoxicity, anti-inflammation, neuroprotection, antifungal, and anti-malarial activities. This review covers publications from the first identification of lindeneol in 1925-2023 and classifies the lindenane sesquiterpenoid derivatives into sesquiterpenoid monomers, sesquiterpenoid-monoterpene conjugates, sesquiterpenoid homodimers, sesquiterpenoid heterodimers, and trimeric sesquiterpenoids. In addition, their biological activities are summarized. This review will establish a scientific basis and provide guidance for utilizing this unique class of natural products as potential lead compounds to develop their application in treating diseases corresponding to inflammation, cancer, and plasmodium.Copyright © 2023. Published by Elsevier Ltd.