以軟組織肉瘤患者療程中的放射治療和切除的順序問題，通常需要個體化討論。深入了解輔助放射治療（ART）和新輔助放射治療（NART）對健康相關生活質量（QoL）之潛在差異，將有助於臨床決策的做出。來自39家醫院的成年肉瘤患者完成了歐洲癌症研究與治療組織（EORTC）生活質量核心問卷（QLQ-C30）。利用多變量回歸分析，校正年齡、性別、化療、分級、期別、腫瘤部位、復發/遠處轉移、肉瘤類型、距上次治療時間和治療狀態等驗證的閾值，研究了ART對比NART之間的整體QoL、身體功能、角色功能、疲勞、疼痛和失眠之差異。共有1110名患者參與了研究。其中，340人接受了放射治療（NART：n=95，28%；ART：n=245，72%）。在NART之後，整體QoL平均為59.3，而ART之後為60.5（Badj=1.0，p=0.74）。身體功能為65.9對比70.5（Badj=4.2，p=0.16），角色功能為48.8對比56.7（Badj=7.0，p=0.08），疲勞為47.5對比45.4（Badj=-1.2，p=0.71），疼痛為40.2對比34.1（Badj=-6.8，p=0.08），失眠為33.7對比41.6（Badj=5.5，p=0.16）。在接受NART的患者中，相較於治療後<2年（平均n=4），2年後的治療患者出現臨床相關的QoL的損害較少（平均n=6）。大多數領域和整體QoL之間兩種放療組別之間的證據很少。然而，與ART後患者相比，接受NART的患者可能會出現更嚴重的角色功能和疼痛問題，但失眠問題較少。版權所有©2023 Elsevier B.V.。保留所有權利。

The sequence of radiotherapy and resection in patients with soft tissue sarcomas is usually discussed on an individual basis. Better understanding of potential differences of health-related quality of life (QoL) between patients undergoing adjuvant (ART) versus neoadjuvant radiotherapy (NART) is therefore helpful for clinical decision making.Adult sarcoma patients from 39 hospitals completed the European Organisation for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ-C30). Differences in global QoL, physical functioning, role functioning, fatigue, pain, and insomnia between ART versus NART were investigated with multivariate regression, adjusting for age, gender, chemotherapy, grading, stage, tumor location, recurrence/distant metastasis, sarcoma type, time since last treatment, and treatment status using validated thresholds.A total of 1110 patients participated. Of them, 340 had received radiotherapy (NART: n=95, 28%; ART: n=245, 72%). Global QoL was 59.3 on average after NART and 60.5 after ART (Badj=1.0, p=0.74). Physical functioning was 65.9 compared to 70.5 (Badj=4.2; p=0.16), role function 48.8 vs. 56.7 (Badj=7.0, p=0.08), fatigue 47.5 vs. 45.4 (Badj=-1.2; p=0.71), pain 40.2 vs. 34.1 (Badj=-6.8; p=0.08), and insomnia 33.7 vs. 41.6 (Badj=5.5, p=0.16). Among patients with NART, clinically relevant QoL impairments were less frequent 2 years after treatment compared to <2 years thereafter (n=6 vs. n=4 on average).There is little evidence for QoL differences in most domains and overall QoL between the two irradiation groups. However, patients after NART might experience worse role functioning and pain but fewer problems with insomnia compared to patients after ART.Copyright © 2023 Elsevier B.V. All rights reserved.