缺乏维生素D是一种具有多种原因的疾病。它与多种共病有关，如自身免疫性疾病、骨病、癌症、心血管疾病、神经退行性疾病、精神疾病以及呼吸道感染如COVID-19。由于其在全球范围内的高患病率，这对全球的医疗保健系统来说是一项重要任务。由于日照时间不足、营养不足以及与年龄相关的皮肤、肝脏和肾脏功能变化的结合作用，老年人和居住在养老院的居民尤其是存在严重发展维生素D缺乏的风险。本回顾性研究分析了奥地利养老院老年人维生素D缺乏症（血清25-羟基维生素D [25（OH）D] < 12 ng/ml）的患病率。同时，还使用皮尔逊相关系数检验了人口统计数据和其他实验室指标如钙与维生素D水平之间的关系。通过散点图和回归线对这种相关性进行了图形化说明。包括了2017年1月3日至2020年8月31日期间在维也纳的一所养老院入住的478名患者。总计106名老年人（占22.2%）患有明显的维生素D缺乏症。男性的维生素D水平显著低于女性的水平（22.9 ± 12.6 ng/ml vs. 26.2 ± 14.8 ng/ml，p = 0.027）。参与者的维生素D血清水平与其血清钙水平显著相关（r=0.19，p<0.001）。478名养老院居民中有39.5%（189名）的血清维生素D水平不足。总之，可以说养老院居民维生素D缺乏症的患病率相当高。维生素D水平不足通常与钙水平降低有关。鉴于患病率高、不足水平的众多负面健康后果以及较大的治疗指数，这个高风险群体应该每天补充25 μg（1000 IU）的维生素D3。此外，在补充治疗开始后的三个月内应进行血液检查。如果一些居民无法达到适当的维生素D浓度，补充治疗必须根据个体需求进行调整，以尽可能精确地治疗。版权所有 © 2023 作者。由Elsevier Ltd.出版。保留所有权利。

Vitamin D deficiency is a condition with different causes. It is associated with numerous comorbidities such as autoimmune diseases, bone diseases, cancer, cardiovascular diseases, neurodegenerative diseases, psychiatric diseases, and respiratory infections like COVID-19. Due to its high prevalence all over the world, it is a major task for health care systems worldwide. Through a combination of low sunlight exposure, insufficient nutrition, and age-related changes in skin, liver, and kidney function, especially seniors and nursing home residents, in particular, have a significantly increased risk of developing a vitamin D deficiency.This retrospective study analyzed the prevalence of vitamin D deficiency (serum 25-hydroxyvitamin D [25(OH)D] < 12 ng/ml) amongst selected Austrian nursing home seniors. It also examined whether demographic data and other laboratory values like calcium correlate with vitamin D levels by using the Pearson correlation coefficient. This correlation was graphically illustrated with a scatter plot and regression line. A total of 478 patients admitted to a nursing home in Vienna between January 3, 2017, and August 31, 2020, were included.A total of 106 seniors (22,2%) suffered from a manifest vitamin D deficiency. The vitamin D level of the men was significantly lower than the level of the women (22.9 ± 12.6 ng/ml vs. 26.2 ± 14.8 ng/ml, p = 0.027). The vitamin D serum levels significantly correlated with the serum calcium levels of the participants (r = 0.19, p < 0.001). 39.5% (189 out of 478) of the nursing home residents had inadequate serum vitamin D levels.In summary, it can be said that the prevalence of vitamin D deficiency among nursing home residents is considerably high. Inadequate vitamin D levels were often associated with reduced calcium levels. Given the high prevalence, the numerous negative health consequences of inadequate levels, and the large therapeutic index, this risk group should get a general supplementation with a dose of 25 μg (1000 IU) vitamin D3 per day. In addition, a blood examination should be performed as early as three months after the start of the supplementation therapy. If some residents do not achieve an adequate vitamin D concentration, the substitution has to be adapted to the individual needs to treat them as precisely as possible.Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.