癌症一直是人类健康的最大威胁，然而传统的治疗方法，如手术、化疗和放疗的效果并不令人满意。目前，基于纳米医学的化学免疫疗法可以通过独特的协同效应改善临床治疗结果。然而，目前主要基于肿瘤局部EPR效应在肿瘤部位富集，缺乏主动传递策略且具有相对较低的肿瘤靶向分布。因此，制备了具有磁响应性和类酶活性的纳米机器人（Cu@MPS-GOD），可以在3D磁场作用下富集并移动到肿瘤部位，并通过级联催化芬顿反应引发肿瘤细胞免疫性死亡。与此同时，Cu@MPS-GOD还可以激活免疫细胞或诱导癌细胞暴露表面抗原，启动全身抗癌免疫反应，并在小鼠乳腺肿瘤模型中显示了良好的抑制效果，抑制率为59.3%。这项研究为在化学动力疗法结合免疫疗法时扩大癌症治疗效果提供了一种有吸引力的策略，具有潜在的临床应用前景。

Cancer has always been the biggest threat to human health, but the effect of traditional treatments such as surgery, chemotherapy, and radiotherapy is not satisfactory. Currently, nanomedicine-based chemoimmunotherapy can improve clinical results through unique synergistic effects. However, it is mainly enriched at tumor sites based on EPR effects, without an active delivery strategy and relatively low tumor targeting distribution. Therefore, nanorobots (Cu@MPS-GOD) with magnetic responsiveness and enzyme-like activity were prepared, which can enrich and move to the tumor site under the action of a 3D magnetic field, and cause tumor cell immunogenic death by cascade catalytic Fenton reactions. Meanwhile, Cu@MPS-GOD can also activate immune cells or induce cancer cells to expose surface antigens, trigger systemic anti-cancer immunity, and have a good inhibitory effect on a breast tumor model in mice with an inhibition rate of 59.3%. This work provides an attractive strategy to expand the therapeutic effect of cancer when chemical dynamic therapy is combined with immunotherapy, which has a potential clinical application prospect.