鼻窦结构及其相邻器官担负着多项功能，包括视觉、嗅觉、鼻腔呼吸和过滤、分泌的免疫功能、面部表情、语言表达和口腔吞咽。本文回顾了当前支持鼻窦癌治疗中功能保护的证据。鼻窦癌的标准治疗仍然是原发手术，或联合辅助疗法。不幸的是，功能妥协仍然是这种方法的主要负面特征。最近，通过治疗技术的进步和对相关肿瘤生物学的改进认识，旨在保护功能和美容的治疗方法正在出现。本文重点介绍了涉及最小创伤手术、康复性外科重建、放射治疗的新技术、全身和局部增强化疗的包含、以及基于分子靶点的治疗药物的证据。这种多管齐下的方法对于未来的鼻窦癌患者进行成功的治疗，并最大限度地保护关联功能，具有良好前景。© 2023 Wiley Periodicals LLC.

The sinonasal structures and their adjacent organs host several functions including vision, olfaction, nasal respiration and filtration, secretory immunity, facial expression, articulation, and oral deglutition. We reviewed the current evidence supporting functional preservation in sinonasal cancer treatment. Primary surgery with or without adjuvant modalities continues to be the standard of care for sinonasal cancer. Unfortunately, functional compromise remains a dominant negative feature of this approach. More recently, through advances in therapeutic techniques and improved understanding of the relevant tumor biology, treatments aimed at preserving function and cosmesis are emerging. The evidence for such progress involving minimal access surgery, surgical reconstruction for rehabilitation, new techniques in radiation therapy, inclusion of systemic and locally enhanced chemotherapy, and therapeutic agents based on molecular targets are highlighted. This multi-prong approach bodes well for future patients with sinonasal cancer to undergo successful treatment that includes maximal preservation of associated functions.© 2023 Wiley Periodicals LLC.