胰腺癌是美国第三大致癌死因，由于其侵袭性特点和治疗选择有限，新治疗方法的需求日益凸显。近期的研究表明植物源化合物（植物化学物质）在胰腺癌治疗上具有潜在的疗效。本综述的目的是评估植物化学物质在胰腺癌治疗和预防中的潜力。本综述应用“系统评述和Meta分析的推荐报告项目”(Preferred Reporting Items for Systematic Reviews and Meta-Analyses)来收集相关文章。通过查询学术数据库PubMed, Scopus和ScienceDirect，使用以下关键词进行检索：植物化学物质，酚类化合物，萜类化合物，生物碱，含硫化合物，体外，体内，临床研究，胰腺癌，肿瘤，治疗和预防。从合格的研究中汇总的结果表明植物化学物质可以抑制胰腺癌细胞的生长，或在动物模型中减小肿瘤的大小和体积。这些效果归因于多种机制，例如增加促凋亡因子，减少抗凋亡因子，或诱导细胞死亡和细胞周期阻滞。植物化学物质调节的值得注意的信号通路包括大鼠肉瘤/丝裂原活化蛋白激酶、翅膀相关整合位点/β-连环蛋白和磷酸肌醇-3-激酶/蛋白激酶B/雷帕霉素靶蛋白信号转导通路。在临床上，植物化学物质通过提高生存率表现出良好的耐受性和安全性，尽管研究相对较少。尽管这些有希望的结果引起了该领域的极大兴趣，但在将植物化学物质用于预防或治疗胰腺癌之前，需要进一步深入的研究来验证其抗癌活性。本文受版权保护，禁止复制。

Pancreatic cancer is the third leading cause of cancer-related deaths in the United States, owing to its aggressive nature and suboptimal treatment options, emphasizing the need for novel therapeutic approaches. Emerging studies have exhibited promising results regarding the therapeutic utility of plant-derived compounds (phytochemicals) in pancreatic cancer. The purpose of this review is to evaluate the potential of phytochemicals in the treatment and prevention of pancreatic cancer. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses was applied to collect articles for this review. Scholarly databases, including PubMed, Scopus, and ScienceDirect, were queried for relevant studies using the following keywords: phytochemicals, phenolics, terpenoids, alkaloids, sulfur-containing compounds, in vitro, in vivo, clinical studies, pancreatic cancer, tumor, treatment, and prevention. Aggregate results pooled from qualified studies indicate phytochemicals can inhibit pancreatic cancer cell growth or decrease tumor size and volume in animal models. These effects have been attributed to various mechanisms, such as increasing proapoptotic factors, decreasing antiapoptotic factors, or inducing cell death and cell cycle arrest. Notable signaling pathways modulated by phytochemicals include the rat sarcoma/mitogen activated protein kinase, wingless-related integration site/β-catenin, and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signal transduction pathways. Clinically, phytochemicals have been found to increase survival while being well-tolerated and safe, though research is scarce. While these promising results have produced great interest in this field, further in-depth studies are required to characterize the anticancer activities of phytochemicals before they are utilized to prevent or treat pancreatic cancer in clinical practice.This article is protected by copyright. All rights reserved.