使用干细胞衍生的器官样体在建模重症急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染方面，有助于我们对COVID-19疾病的分子发病机制的理解，因为它们与实际人体组织或器官相似。过去十年里，器官样体的三维（3D）培养代表了与传统二维（2D）细胞培养相比的新视角和显著进展。COVID-19疾病会导致肺损伤和多器官衰竭，尤其是在年长的患者中。在疫情期间，急需生理模型来研究SARS-CoV-2感染。人类干细胞衍生的器官样体可以深入了解SARS-CoV-2细胞进入的分子机制。识别这种复杂性将有助于开发最佳的预防药物靶点。© 2023. Crown.

Modeling severe acute respiratory syndrome, Coronavirus 2 (SARS-CoV-2) infection in stem cell-derived organoids has helped in our understanding of the molecular pathogenesis of COVID-19 disease due to their resemblance to actual human tissues or organs. Over the past decade, organoid 3-dimensional (3D) cultures have represented a new perspective and considerable advancement over traditional in vitro 2-dimensional (2D) cell cultures. COVID-19 disease causes lung injury and multi-organ failure leading to death, especially in older patients. There is an urgent need for physiological models to study SARS-CoV-2 infection during the pandemic. Human stem cell-derived organoids can provide insight into understanding the SARS-CoV-2 cell entry molecular mechanism. Identifying such complexities will help to develop the best preventive drug targets.© 2023. Crown.