尽管癌症治疗取得了重大进展，但化学治疗仍然是许多肿瘤的治疗基石。然而，需要重要指出，化学治疗引起的毒性作用，包括肝毒性，可能会导致潜在有效治疗的中断或停止。近年来，人们特别关注寻找辅助疗法以减轻化学治疗引起的毒性作用。目前虽然缺乏特定干预措施来减轻或预防化学治疗患者的肝毒性，但多酚化合物姜黄素已经出现作为克服这种不良反应的潜在策略。本文首先回顾了化学治疗引起的肝毒性的分子和生理机制以及主要风险因素。然后我们概述了姜黄素如何通过针对特定的分子机制减轻肝毒性的潜力。肝毒性是细胞毒性药物的明确副作用，可能限制其临床应用。炎症和氧化应激是肝毒性中最常见的机制。多项研究表明，姜黄素可以预防和/或减轻化学治疗引起的肝损伤，主要是由于其抗炎、抗氧化、抗纤维化和降脂作用。有必要进一步进行临床调查，使用可生物利用性的姜黄素制剂以证明其在癌症患者中作为肝脏保护剂的功效。 版权所有 © 2023. 由 Elsevier 公司出版。

Despite significant advances in cancer therapeutics, chemotherapy remains the cornerstone of treatment for many tumors. Importantly, however, chemotherapy-induced toxicity, including hepatotoxicity, can lead to the interruption or discontinuation of potentially effective therapy. In recent years, special attention has been paid to the search for complementary therapies to mitigate chemotherapy-induced toxicity. Although there is currently a lack of specific interventions to mitigate or prevent hepatotoxicity in chemotherapy-treated patients, the polyphenol compound curcumin has emerged as a potential strategy to overcome this adverse effect. Here we review, firstly, the molecular and physiological mechanisms and major risk factors of chemotherapy-induced hepatotoxicity. We then present an overview of how curcumin has the potential to mitigate hepatotoxicity by targeting specific molecular mechanisms. Hepatotoxicity is a well-described side effect of cytotoxic drugs that can limit their clinical application. Inflammation and oxidative stress are the most common mechanisms involved in hepatotoxicity. Several studies have shown that curcumin could prevent and/or palliate chemotherapy-induced liver injury, mainly due to its anti-inflammatory, antioxidant, antifibrotic and hypolipidemic properties. Further clinical investigation using bioavailable curcumin formulations is warranted to demonstrate its efficacy as an hepatoprotective agent in cancer patients.Copyright © 2023. Published by Elsevier Inc.