运动被认为在减少某些癌症的风险方面具有潜在作用。然而，这种风险降低的分子机制尚未完全理解。在这里，我们假设有氧运动通过调节氧化应激和炎症来诱导抗癌效应。为了测试这个假设，我们将二十只雄性SD大鼠分为两组：前列腺癌（PC）无运动和有运动（PC+Ex）。PC+Ex组的大鼠在8周内进行如下的有氧运动：每周5次，每次持续60%最大运动容量的强度，在跑步机上进行。分析了体重和饲料效率、Ki-67、细胞凋亡、前列腺炎症和氧化应激指标。我们发现有氧运动显著降低了前列腺细胞增殖（p<0.05）。PC+Ex组也显著降低了抗凋亡蛋白的表达（p<0.05），并增加了促凋亡蛋白的表达。此外，有氧运动增加了前列腺、血浆和全血中酶性抗氧化防御。此外，PC+Ex组降低了脂质过氧化和蛋白质碳基水平（p<0.05）。在前列腺中，有氧运动增加了抗炎细胞因子（IL-10）的水平，并在8周的运动后降低了炎症细胞因子（IL-6、TNF-α和NF-κB）的水平。总之，我们发现有氧运动是控制前列腺癌进展的功能性、有益且适用的方法，因为它改变了系统环境，包括对葡萄糖和循环脂肪的调节。该癌细胞环境的修正具有抗炎和抗氧化效应，能够减轻肿瘤生长。（版权所有 © 2023 Elsevier Inc.）

Exercise is recognized for its potential role in reducing the risk of certain cancers. However, the molecular mechanisms behind this risk reduction are not fully understood. Here, we hypothesized that aerobic physical exercise induces cancer attenuating effects through the modulation of oxidative stress and inflammation. To test this hypothesis, twenty male Sprague Dawley rats with chemically induced prostate tumors were divided into two groups: Prostate cancer (PC) in the absence and presence of exercise (PC + Ex). Rats in the PC + Ex group performed exercises on a treadmill for 8 weeks, 5 sessions per week, at an intensity of 60 % of maximum capacity. Weight and feed efficiency, Ki-67, apoptosis, prostatic inflammation, and markers of oxidative stress were analyzed. We found that aerobic physical exercise significantly decreased prostate cell proliferation (p < 0.05) across modulation, tumor size, and prostate weight. The PC + Ex group also significantly reduced anti-apoptosis protein expression (p < 0.05) and increased pro-apoptotic protein expression. Furthermore, physical exercise increased enzymatic antioxidant defenses in the prostate, plasma, and whole blood. Moreover, PC + Ex reduced lipid peroxidation and protein carbonyl levels (p < 0.05). In the prostate, there was an increase in anti-inflammatory cytokines (IL-10), and a reduction in pro-inflammatory cytokines (IL-6, TNF-α, and NF-κB) after 8 weeks of physical exercise. In conclusion, we found that aerobic physical exercise is a functional, beneficial, and applicable approach to control PC progression, because it modifies the systemic environment, including the regulation of glucose and circulating lipids. This modification of the cancer cells environment has anti-inflammatory and antioxidant effects that attenuate tumor growth.Copyright © 2023. Published by Elsevier Inc.