研究动态
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乳腺癌的成像特征与分子亚型的相关性。

Correlation of Imaging Findings with Molecular Subtypes of Breast Cancer.

发表日期:2023 Sep 08
作者: Om Biju Panta, Vivek Dhakal, Bibek Gurung, Ram Kumar Ghimire
来源: Cellular & Molecular Immunology

摘要:

超声和乳腺X线摄影是乳腺癌的首选成像方法。恶性乳腺病变的处理取决于肿瘤细胞中的分子生物标记物。本研究旨在将不同的乳腺癌成像结果与免疫组织化学亚型相关联。该研究是一项回顾性研究,时间跨度为2018年1月至2021年12月。纳入了接受乳腺病变超声引导活检的恶性乳腺病变患者。我们检索并分析了这些患者在PACS中的超声和乳腺X线摄影结果。根据分子标记物,将恶性乳腺病变分为Luminal A、Luminal B、Her-2丰富型和三阴性乳腺癌。分析了成像结果与乳腺癌分子亚型之间的相关性。研究共纳入了42例患者。我们研究的患者平均年龄为52.24+/-13.54岁,中位数为51岁(四分位距范围-19.5岁)。最常见的免疫组织化学亚型类型是Luminal B(22例,52.4%),其次是三阴性(15例,35.7%),Luminal A(4例,9.5%),最少见的是Her-2丰富型(1例,2.4%)。乳腺X线摄影在9.5%的病例中无法诊断。与其他亚型相比,超声中的椭圆形状和良好边缘与三阴性乳腺癌更常见相关(P<0.05)。我们研究中的三阴性和其他恶性病变的其他特征没有显著差异。各种亚型之间的乳腺X线摄影结果没有显著差异。在我们的人群中,三阴性乳腺癌比西方地区更常见。三阴性乳腺癌通常具有清晰的椭圆形状,与良性病变类似。
Ultrasound and Mammography are first-line imaging in breast cancer. The management of malignant breast lesions depends on molecular biomarkers in the tumor cells. This study aims to correlate different imaging findings in breast carcinoma with immune-histology subtypes.The study was a retrospective study conducted between 2018 January to 2021 December. Patients with malignant breast lesions who underwent USG-guided biopsy of breast lesions were included in the study. Ultrasound and mammographic findings of these patients were retrieved in PACS and analyzed. Malignant breast lesions were classified according to molecular markers into Luminal A, Luminal B, Her- 2 enriched, and triple-negative breast cancers. The correlation between imaging findings and molecular subtypes of breast cancer was analyzed.A total of 42 patients were included in the study. The mean age of the patients in our study was 52.24+/-13.54 years with median of 51 years (IQ range-19.5 years). The most common IHC subtype was Luminal type B (22, 52.4%), followed by triple negative (15, 35.7%), luminal type A (4, 9.5%) and least common was Her-2 enriched (1, 2.4%). Mammogram was non-diagnostic in 9.5% of case. Oval shape and well marginated margin in ultrasound were more frequently associated with triple negative breast cancer than other subtypes (P<0.05). Rest of the characteristics of triple negative and other malignancies were not significantly difference in our study. No significant difference is noted between mammographic findings between various subtypes.Triple negative breast cancer was more common in our population than in the west. Triple-negative breast cancers are more frequently well-defined and oval in shape mimicking benign lesions.