K-Ras纳米簇（NCs）在一个小范围内集中所有属于细胞外信号调控激活的蛋白激酶（ERK）丝裂原活化蛋白激酶（MAPK）信号通路所需的分子，在此处发生信号事件，增加信号传导的效率和特异性。这种纳米结构特征是由控制尺寸和寿命分布所决定的，但对其生长/衰减动力学机制了解甚少。因此，本文提出了一个最小计算模型来分析K-Ras NC作为协同动态结构的行为，其按照其尺寸自我调节其生长和衰减。事实上，所提出的模型揭示了K-Ras纳米簇的生长和局部产生与其实际尺寸正相关，同时其寿命与其尺寸的平方根成反比。NC的结构成分（K-Ras蛋白）之间的协同结合导致K-Ras NC尺寸分布产生振荡，使其在控制范围内变化，调节这些NC的生长/衰减动力学。因此，K-Ras NC的尺寸被提出作为调节细胞信号传导的关键因素，为慢性疾病和癌症的治疗提供了一系列可能性。版权所有©2023作者，Elsevier有限公司发表。保留所有权利。

K-Ras nanoclusters (NCs) concentrate all required molecules belonging to the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) pathway in a small area where signaling events take place, increasing efficiency and specificity of signaling. Such nanostructures are characterized by controlled sizes and lifetimes distributions, but there is a poor understanding of the mechanisms involved in their dynamics of growth/decay. Here, a minimum computational model is presented to analyze the behavior of K-Ras NCs as cooperative dynamic structures that self-regulate their growth and decay according to their size. Indeed, the proposed model reveals that the growth and the local production of a K-Ras nanocluster depend positively on its actual size, whilst its lifetime is inversely proportional to the root of its size. The cooperative binding between the structural constituents of the NC (K-Ras proteins) induces oscillations in the size distributions of K-Ras NCs allowing them to range within controlled values, regulating the growth/decay dynamics of these NCs. Thereby, the size of a K-Ras NC is proposed as a key factor to regulate cell signaling, opening a range of possibilities to develop strategies for use in chronic diseases and cancer.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.