对于抗癌药物的成功药理作用，抗凋亡的抵抗是一个阻碍。全面深入地了解凋亡信号通路以及抵抗凋亡机制对于揭示新的药物靶标至关重要。在这个关键时刻，研究人员正朝着天然来源，特别是蘑菇，作为潜在药物的可靠来源的方向前进。鉴于癌症病例的持续增加，蘑菇的强效抗癌功效不可避免地成为研究人员的研究对象，因为其有着更高的安全边际和多靶点。该综述旨在收集和总结关于蘑菇的所有可用科学数据，包括从其提取物到生物活性分子，以建议其通过线粒体介导的内在信号通路机制的抗癌属性。总结的数据显示，包括多糖、甾醇和萜类化合物在内的蘑菇的生物活性成分以及使用15种不同溶剂制备的提取物来自53种蘑菇，可以在20种不同的癌症的辅助治疗中发挥有效作用。本综述通过多样化和互补的研究方法探讨了所研究的蘑菇的潜在治疗机制：体外实验、临床前研究和临床随机对照试验。主要涉及的过程包括ROS产生、线粒体膜功能失调以及caspase 3、caspase 9、XIAP、cIAP、p53、Bax和Bcl-2的作用。总之，该研究提供了关于蘑菇提取物及其活性化合物对各种癌症的潜在有益效果并揭示了潜在的靶向信号通路的事实。版权所有©2023。Elsevier B.V.出版。

Resistance to apoptosis stands as a roadblock to the successful pharmacological execution of anticancer drug effect. A comprehensive insight into apoptotic signaling pathways and an understanding of the mechanisms of apoptosis resistance are crucial to unveil new drug targets. At this juncture, researchers are heading towards natural sources in particular, mushroom as their potential drugs leads to being the reliable source of potent bioactive compounds. Given the continuous increase in cancer cases, the potent anticancer efficacy of mushrooms has inevitably become a fascinating object to researchers due to their higher safety margin and multitarget. This review aimed to collect and summarize all the available scientific data on mushrooms with from their extracts to bioactive molecules in order to suggest their anticancer attributes via a mitochondrion -mediated intrinsic signaling mechanism. Compiled data revealed that bioactive components of mushrooms including polysaccharides, sterols and terpenoids as well as extracts prepared using 15 different solvents from 53 species could be effective in the supportive treatment of 20 various cancers. The underlying therapeutic mechanisms of the studied mushrooms are explored in this review through diverse and complementary investigations: in vitro assays, pre-clinical studies and clinical randomized controlled trials. The processes mainly involved were ROS production, mitochondrial membrane dysfunction, and action of caspase 3, caspase 9, XIAP, cIAP, p53, Bax, and Bcl-2. In summary, the study provides facts pertaining to the potential beneficial effect of mushroom extracts and their active compounds against various types of cancer and is shedding light on the underlying targeted signaling pathways.Copyright © 2023. Published by Elsevier B.V.