血液透析（HD）患者普遍存在脆弱状态。尚未确认HD患者脆弱状态与运动能力之间的关联。本研究旨在阐明HD患者脆弱状态与运动能力之间的关系。这项两个中心的横断面研究纳入了进行心肺运动测试的HD患者。根据修订版日本版本的心血管健康研究标准，被纳入研究的参与者按照脆弱状态表型分为有强壮、亚脆弱和脆弱的人群。采用心肺运动测试测量的峰值氧摄入量（峰值VO2）与每种脆弱状态进行比较。多元线性回归分析用于分析峰值VO2与脆弱状态之间的关联，根据年龄、性别、体重指数、糖尿病、心血管疾病、癌症、骨折史、血红蛋白、左室射血分数和心率储备百分比进行调整。该研究纳入了136名患者（年龄中位数为71.0岁，女性占23.5%），其中15.4%、44.9%和39.7%的患者表现为强壮、亚脆弱和脆弱状态。随着脆弱状态恶化，峰值VO2下降（强壮，中位数为15.1 [13.7-18.3] mL/min/kg；亚脆弱，中位数为12.2 [10.5-14.4] mL/min/kg；脆弱，中位数为10.6 [9.2-12.5] mL/min/kg，P<0.05）。脆弱状态显著与峰值VO2下降相关（B=-2.19，P=0.004）。对个体脆弱状态组成部分进行建模显示，峰值VO2与常规步态速度（B=2.38，P=0.04）和低身体活动量（B=-1.44，P=0.004）存在显著关联。HD患者脆弱状态与运动能力下降相关，需要改善运动能力、步态速度和身体活动量。《老年学与老年病学国际期刊》2023年;••:••-••。©2023年日本老年医学会。

Hemodialysis (HD) patients have a high prevalence of frailty. The association between frailty and exercise capacity in HD patients has not been established. This study aimed to clarify the relationships between frailty and exercise capacity in HD patients.This two-center cross-sectional study included HD patients who performed cardiopulmonary exercise testing. Participants were divided by frailty phenotype into robust, pre-frail, and frail using the revised Japanese version of the Cardiovascular Health Study criteria. Peak oxygen uptake (peakVO2 ) measured by cardiopulmonary exercise testing was compared with each frailty phenotype. The association between peakVO2 and frailty phenotype was analyzed using multivariate linear regression analysis adjusted for age, sex, body mass index diabetes mellitus, cardiovascular disease, cancer, history of fracture, hemoglobin, left ventricle ejection fraction, and percentage of heart rate reserve.The study included 136 patients (median age, 71.0 years; female, 23.5%), with 15.4%, 44.9%, and 39.7% with frailty phenotypes robust, pre-frail, and frail, respectively. PeakVO2 decreased with deterioration of the frailty phenotype (robust, median 15.1 [13.7-18.3] mL/min/kg; pre-frail, median 12.2 [10.5-14.4] mL/min/kg; frail, median 10.6 [9.2-12.5] mL/min/kg, P < 0.05). PeakVO2 decline was significantly associated with frail (B = -2.19, P = 0.004). Modeling individual frailty components showed a significant association between peakVO2 , usual gait speed (B = 2.38, P = 0.04), and low physical activity (B = -1.44, P = 0.004).Frailty in HD patients was associated with a decline in exercise capacity. HD patients with frailty need to improve exercise capacity, gait speed, and physical activity. Geriatr Gerontol Int 2023; ••: ••-••.© 2023 Japan Geriatrics Society.