经内窥镜超声引导下用19号针进行细针穿刺（EUS-FNA）是诊断淋巴结病变的有效采样方法。本研究对比了19号经典针和Franseen针在淋巴结病变诊断和恶性淋巴瘤（ML）分类中的表现。分析了通过采用经典或Franseen针进行EUS-FNA诊断淋巴结病变的患者的特征、针穿次数、穿刺路径、淋巴结病变的细胞学/组织学的敏感性、特异性和准确性。在2012年至2022年间，共有146名符合纳入标准的患者（经典针组n=70，Franseen针组n=76）。经典组的中位针穿次数显著低于Franseen组（3 [1-6] vs. 4 [1-6]，p=0.023）。两组之间在细胞学/组织学诊断上没有显著差异。就ML而言，在两组中，免疫组织化学评估率、流式细胞术的敏感性以及细胞遗传学评估结果都没有显著差异。Franseen组有3例患者出现出血不良事件（AEs）。19号经典针和Franseen针在淋巴结病变和ML分类中都显示出较高的准确性。考虑到足够的组织获取和避免不良事件的发生，19号经典针似乎是诊断淋巴结病变的较好选择。

Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) using a 19-gauge needle is an efficient sampling method for the diagnosis of lymphadenopathy. This study compared 19-gauge conventional and Franseen needles for the diagnosis of lymphadenopathy and classification of malignant lymphoma (ML).Patient characteristics, number of needle passes, puncture route, sensitivity, specificity, and accuracy of cytology/histology for lymphadenopathy were analyzed in patients diagnosed with lymphadenopathy by EUS-FNA using conventional or Franseen needles.Between 2012 and 2022, 146 patients met the inclusion criteria (conventional [n=70] and Franseen [n=76]). The median number of needle passes was significantly lower in the conventional group than in the Franseen group (3 [1-6] vs. 4 [1-6], p=0.023). There were no significant differences in cytological/histological diagnoses between the two groups. For ML, the immunohistochemical evaluation rate, sensitivity of flow cytometry, and cytogenetic assessment were not significantly different in either group. Bleeding adverse events (AEs) were observed in three patients in the Franseen group.Both the 19-gauge conventional and Franseen needles showed high accuracy in lymphadenopathy and ML classification. Considering sufficient tissue collection and the avoidance of AEs, the use of 19-gauge conventional needles seems to be a good option for the diagnosis of lymphadenopathy.