准确的肿瘤定位对于精确的手术靶向和彻底切除肿瘤至关重要。吲哚菁绿荧光是一种在肿瘤外科手术中越来越多使用的技术，在定位不可触及的乳腺肿瘤方面显示出前景。本系统综述的目的是描述吲哚菁绿荧光识别不可触及乳腺肿瘤的功效。在 PubMed、Embase 和 Cochrane 图书馆进行了系统文献检索，包括 2012 年至 2023 年的研究。研究报告包括使用吲哚菁绿荧光识别的乳腺肿瘤的比例。使用非随机研究方法指数（“MINORS”）工具评估研究的质量及其偏倚风险。收集以下结果：识别率、清晰的切除边缘、标本体积、手术时间、再次手术率、不良事件和并发症。总共筛选了 2061 篇文章的资格，产生了 11 项研究，纳入了 366 名患者：两项随机对照研究、三项非随机比较研究、四项单臂研究和两份病例报告。除一项研究的识别率为 87% (13/15) 外，所有研究均通过吲哚菁绿荧光实现了 100% 的肿瘤识别率。 88-100% 的所有患者均发现清晰的切除边缘。再手术率在0.0%至5.4%之间，并且没有发生与吲哚菁绿相关的并发症或不良事件。与目前的常规定位方法相比，吲哚菁绿荧光具有显着的理论优势。尽管可用的研究数量有限，但目前的文献表明，吲哚菁绿荧光对于术中定位不可触及的乳腺肿瘤来说是一种有用、准确和安全的技术，与其他定位技术相比具有相当的功效，有可能减少肿瘤的发生。正利润率。© 作者 2023。由牛津大学出版社代表 BJS Society Ltd 出版。

Accurate tumour localization is crucial for precise surgical targeting and complete tumour removal. Indocyanine green fluorescence, an increasingly used technique in oncological surgery, has shown promise in localizing non-palpable breast tumours. The aim of this systematic review was to describe the efficacy of indocyanine green fluorescence for the identification of non-palpable breast tumours.A systematic literature search was performed in PubMed, Embase, and the Cochrane Library, including studies from 2012 to 2023. Studies reporting the proportion of breast tumours identified using indocyanine green fluorescence were included. The quality of the studies and their risk of bias were appraised using the Methodological Index for Non-Randomized Studies ('MINORS') tool. The following outcomes were collected: identification rate, clear resection margins, specimen volume, operative time, re-operation rate, adverse events, and complications.In total, 2061 articles were screened for eligibility, resulting in 11 studies, with 366 patients included: two RCTs, three non-randomized comparative studies, four single-arm studies, and two case reports. All studies achieved a 100 per cent tumour identification rate with indocyanine green fluorescence, except for one study, with an identification rate of 87 per cent (13/15). Clear resection margins were found in 88-100 per cent of all patients. Reoperation rates ranged from 0.0 to 5.4 per cent and no complications or adverse events related to indocyanine green occurred.Indocyanine green fluorescence has substantial theoretical advantages compared with current routine localization methods. Although a limited number of studies were available, the current literature suggests that indocyanine green fluorescence is a useful, accurate, and safe technique for the intraoperative localization of non-palpable breast tumours, with equivalent efficacy compared with other localization techniques, potentially reducing tumour-positive margins.© The Author(s) 2023. Published by Oxford University Press on behalf of BJS Society Ltd.