照亮肿瘤破坏之路。
Lighting the way to tumor destruction.
发表日期：2023 Nov
作者：
Christina C Kuismi, Behnam Nabet
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES
摘要：
在以蛋白水解靶向嵌合体（PROTAC）作为癌症治疗药物的过程中，实现肿瘤特异性蛋白质损失仍然是一个挑战。作为解决方案，Wang 等人。最近开发了纳米配方 PROTAC（NAP），这是一种新型的光活化降解方法。此类创新化合物利用近红外 (NIR) 光在小鼠肿瘤中精确释放 PROTAC 并降解蛋白质。版权所有 © 2023 Elsevier Ltd。保留所有权利。
Achieving tumor-specific protein loss remains a challenge in the delivery of proteolysis-targeting chimeras (PROTACs) as cancer therapeutics. As a solution, Wang et al. recently developed nanoformulated PROTACs (NAPs), a novel photoactivatable degradation approach. This innovative class of compounds harnesses near-infrared (NIR) light for precise PROTAC release and protein degradation in mouse tumors.Copyright © 2023 Elsevier Ltd. All rights reserved.