首次由解脲寡杆菌引起的致命感染:病例报告和文献综述。
The First Lethal Infection by Oligella ureolytica: A Case Report and Review of the Literature.
发表日期:2023 Sep 21
作者:
Pierre Serandour, Chloé Plouzeau, Anthony Michaud, Lauranne Broutin, Julie Cremniter, Christophe Burucoa, Maxime Pichon
来源:
Antibiotics-Basel
摘要:
解尿酸寡杆菌是一种革兰氏阴性杆菌,属于产碱杆菌科,此前从未被报道过具有致命性。本文报道了一名疑似膀胱癌的老年妇女因解尿酸寡杆菌感染而致死的病例。通过对细菌 16S rRNA 序列进行桑格测序并与已发表的序列进行比较进行系统发育分析,确认了物种鉴定。最初使用头孢曲松和苯唑西林进行抗生素治疗,但由于耐药性而不得不更换。头孢吡肟与甲硝唑联合使用,不幸的是未能阻止患者死亡。需要进一步的研究来探索影响解尿酸寡菌感染临床结果的其他因素。
Oligella ureolytica is a Gram-negative bacillus, a member of the Alcaligenaceae family, that had never previously been reported as lethal. Herein, a case of fatal infection caused by Oligella ureolytica in an elderly woman with suspected bladder cancer is reported. The species identification was confirmed through Sanger sequencing of the bacterial 16S rRNA sequence and compared to published sequences for phylogenetic analysis. Initial antibiotic therapy with ceftriaxone and oxacillin was initiated but had to be switched due to resistance. Cefepime in combination with metronidazole was administered, unfortunately failing to prevent the patient's death. Further studies are needed to explore additional factors influencing clinical outcomes in Oligella ureolytica infections.