FBXW10：肝癌中偏向男性的 E3 连接酶。
FBXW10: a male-biased E3 ligase in liver cancer.
发表日期：2023 Nov
作者：
Osheen Sahay, Ganesh Kumar Barik, Sehbanul Islam
来源：
Trends in Cancer
摘要：
Lin 等人最近的两项研究。 Liu 等人揭示了 F-box 和包含 10 (FBXW10) 的 WD 重复结构域介导的泛素化和致癌信号传导的关键作用，作为男性肝细胞癌 (HCC) 患病率较高的主要驱动因素。这些发现揭示了性别偏见癌症的潜在机制，并为基础和临床研究提供了有前景的路线图。版权所有 © 2023 Elsevier Inc. 保留所有权利。
Two recent studies, by Lin et al. and Liu et al., unveiled the pivotal role of F-box and WD repeat domain containing 10 (FBXW10)-mediated ubiquitination and activation of oncogenic signaling as the primary driver behind the higher prevalence of hepatocellular carcinoma (HCC) in men. These discoveries shed light on underlying mechanisms of sex-biased cancer and provide a promising roadmap for both basic and clinical research.Copyright © 2023 Elsevier Inc. All rights reserved.